0 8

Cited 0 times in

Lateral Cortical Thickening and Bone Heterogeneity of the Subtrochanteric Femur Measured With Quantitative CT as Indicators for Early Detection of Atypical Femoral Fractures in Long-Term Bisphosphonate Users

Authors
 Seung Hyun Lee  ;  Young Han Lee  ;  Jin-Suck Suh 
Citation
 American Journal of Roentgenology, Vol.209(4) : 867-873, 2017 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Bone Density ; Bone Density Conservation Agents/adverse effects* ; Diphosphonates/adverse effects* ; Early Diagnosis ; Female ; Femoral Fractures/chemically induced* ; Femoral Fractures/diagnostic imaging* ; Femur/diagnostic imaging* ; Femur/pathology* ; Humans ; Middle Aged ; Retrospective Studies ; Time Factors ; Tomography, X-Ray Computed*
Keywords
atypical femoral fracture ; bisphosphonate ; bone mineral density ; osteoporosis ; quantitative CT (QCT)
Abstract
OBJECTIVE: The objective of our study was to compare subtrochanteric femur bone mineral density (BMD) and bone quality of long-term bisphosphonate (BP) users who sustained an atypical femoral fracture (AFF) with BP users who did not sustain a femoral fracture and BP-naïve patients with no history of femoral fracture using quantitative CT (QCT). MATERIALS AND METHODS: Fourteen female BP users with an AFF (mean age, 72.6 years; mean duration of BP use, 6.2 years; mean body mass index, 21.9) who had undergone QCT before fracture events were sex-, age-, BP use duration-, and body mass index-matched to 14 BP users who did not sustain a fracture and 14 BP-naïve patients. The lateral cortical thickness index (CTI) and the mean BMD (BMDmean) and SD of the BMD (BMDSD) within the lateral cortex and within the entire cross-sectional area of the subtrochanteric femur were measured on axial QCT. Femoral neck-shaft angles were measured on the QCT scout image. Parameters were analyzed using the Kruskal-Wallis test. RESULTS: Lateral CTIs were greater in the BP users with an AFF (median, 0.28) than in the BP users without a femoral fracture (median, 0.21) (p = 0.038) and the BP-naïve group (median, 0.21) (p = 0.009). The lateral cortex BMDSD was significantly higher in the BP users with an AFF (median, 59.59 mg/cm3) than the BP users without a femoral fracture (median, 39.27 mg/cm3; p = 0.049) and the BP-naïve group (median, 31.02 mg/cm3; p = 0.037). There was no significant difference among groups in lateral cortex BMDmean, BMDmean and BMDSD of the entire cross-sectional area, and femoral neck-shaft angle. CONCLUSION: Long-term BP users with a subsequent AFF had a thicker lateral cortex and higher lateral cortex BMDSD at the subtrochanteric area before the fracture on QCT than BP users who did not sustain a femoral fracture and BP-naïve patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161306
DOI
10.2214/AJR.17.17938
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck) ; 이승현(Lee, Seung Hyun) ; 이영한(Lee, Young Han)
사서에게 알리기
  feedback
Full Text
https://www.ajronline.org/doi/abs/10.2214/AJR.17.17938
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse