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Lateral Cortical Thickening and Bone Heterogeneity of the Subtrochanteric Femur Measured With Quantitative CT as Indicators for Early Detection of Atypical Femoral Fractures in Long-Term Bisphosphonate Users

DC Field Value Language
dc.contributor.author서진석-
dc.contributor.author이승현-
dc.contributor.author이영한-
dc.date.accessioned2018-07-20T08:35:15Z-
dc.date.available2018-07-20T08:35:15Z-
dc.date.issued2017-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161306-
dc.description.abstractOBJECTIVE: The objective of our study was to compare subtrochanteric femur bone mineral density (BMD) and bone quality of long-term bisphosphonate (BP) users who sustained an atypical femoral fracture (AFF) with BP users who did not sustain a femoral fracture and BP-naïve patients with no history of femoral fracture using quantitative CT (QCT). MATERIALS AND METHODS: Fourteen female BP users with an AFF (mean age, 72.6 years; mean duration of BP use, 6.2 years; mean body mass index, 21.9) who had undergone QCT before fracture events were sex-, age-, BP use duration-, and body mass index-matched to 14 BP users who did not sustain a fracture and 14 BP-naïve patients. The lateral cortical thickness index (CTI) and the mean BMD (BMDmean) and SD of the BMD (BMDSD) within the lateral cortex and within the entire cross-sectional area of the subtrochanteric femur were measured on axial QCT. Femoral neck-shaft angles were measured on the QCT scout image. Parameters were analyzed using the Kruskal-Wallis test. RESULTS: Lateral CTIs were greater in the BP users with an AFF (median, 0.28) than in the BP users without a femoral fracture (median, 0.21) (p = 0.038) and the BP-naïve group (median, 0.21) (p = 0.009). The lateral cortex BMDSD was significantly higher in the BP users with an AFF (median, 59.59 mg/cm3) than the BP users without a femoral fracture (median, 39.27 mg/cm3; p = 0.049) and the BP-naïve group (median, 31.02 mg/cm3; p = 0.037). There was no significant difference among groups in lateral cortex BMDmean, BMDmean and BMDSD of the entire cross-sectional area, and femoral neck-shaft angle. CONCLUSION: Long-term BP users with a subsequent AFF had a thicker lateral cortex and higher lateral cortex BMDSD at the subtrochanteric area before the fracture on QCT than BP users who did not sustain a femoral fracture and BP-naïve patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringfield, Ill., Thomas-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBone Density-
dc.subject.MESHBone Density Conservation Agents/adverse effects*-
dc.subject.MESHDiphosphonates/adverse effects*-
dc.subject.MESHEarly Diagnosis-
dc.subject.MESHFemale-
dc.subject.MESHFemoral Fractures/chemically induced*-
dc.subject.MESHFemoral Fractures/diagnostic imaging*-
dc.subject.MESHFemur/diagnostic imaging*-
dc.subject.MESHFemur/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, X-Ray Computed*-
dc.titleLateral Cortical Thickening and Bone Heterogeneity of the Subtrochanteric Femur Measured With Quantitative CT as Indicators for Early Detection of Atypical Femoral Fractures in Long-Term Bisphosphonate Users-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorSeung Hyun Lee-
dc.contributor.googleauthorYoung Han Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.identifier.doi10.2214/AJR.17.17938-
dc.contributor.localIdA01916-
dc.contributor.localIdA02934-
dc.contributor.localIdA02967-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid28796551-
dc.identifier.urlhttps://www.ajronline.org/doi/abs/10.2214/AJR.17.17938-
dc.subject.keywordatypical femoral fracture-
dc.subject.keywordbisphosphonate-
dc.subject.keywordbone mineral density-
dc.subject.keywordosteoporosis-
dc.subject.keywordquantitative CT (QCT)-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameLee, Seung Hyun-
dc.contributor.alternativeNameLee, Young Han-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorLee, Seung Hyun-
dc.contributor.affiliatedAuthorLee, Young Han-
dc.citation.volume209-
dc.citation.number4-
dc.citation.startPage867-
dc.citation.endPage873-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.209(4) : 867-873, 2017-
dc.identifier.rimsid61228-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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