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Dielectric imaging for differentiation between cancer and inflammation in vivo

Authors
 Rimi Lee  ;  Sun-Mi Lee  ;  Hyung Joon Kim  ;  Sook Young Kim  ;  Mina Son  ;  Jun Ho Song  ;  Khulan Lkhamsuren  ;  In Ho Park  ;  In Hong Choi  ;  Young Nyun Park  ;  Jeon-Soo Shin  ;  Kyung-Hwa Yoo 
Citation
 Scientific Reports, Vol.7(1) : 13137, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
In this study, we develop an in vivo dielectric imaging technique that measures capacitance using pin-type electrode arrays. Compared to normal tissues, cancer tissues exhibit higher capacitance values, allowing us to image the cancer region and monitor the chemotherapeutic effects of cancer in real-time. A comparison with the histopathological results shows that the in vivo dielectric imaging technique is able to detect small tumors (<3 mm) and tumor-associated changes. In addition, we demonstrate that cancer and inflammation may be distinguished by measuring the capacitance images at different frequencies. In contrast, the positron emission tomography using 2-[18F]-fluoro-2-deoxy-D-glucose was not capable of discriminating between cancer and inflammation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161211
DOI
10.1038/s41598-017-13545-3
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
박영년(Park, Young Nyun) ; 박인호(Park, Inho) ; 신전수(Shin, Jeon Soo) ; 최인홍(Choi, In Hong)
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