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Effect of Serial Use of Bone Morphogenetic Protein 2 and Fibroblast Growth Factor 2 on Periodontal Tissue Regeneration

Authors
 Lee, Ah-Reum  ;  Choi, Hyunmin  ;  Kim, Jee-Hwan  ;  Cho, Sung-Won  ;  Park, Young-Bum 
Citation
 IMPLANT DENTISTRY, Vol.26(5) : 664-673, 2017 
Journal Title
 IMPLANT DENTISTRY 
ISSN
 1056-6163 
Issue Date
2017
Abstract
PURPOSE: This study evaluates the synergistic effect of serial application of bone morphogenetic protein 2 (BMP2) and fibroblast growth factor 2 (FGF2) on both new bone formation and periodontal tissue regeneration using 1-wall intrabony defect in mongrel dogs. MATERIALS AND METHODS: One-wall defects were created at the mesial aspect of the mandibular first molars of 6 male mongrel dogs. Each mandibular defect received 1 of the 2 experimental treatments randomly (BMP2 or BMP2 + FGF2), and it was allowed to heal for either 4 or 8 weeks postoperatively. Histologic and histomorphometric analyses were performed for the evaluation of the overall healing patterns of new bone formation and periodontal tissue regeneration. RESULTS: The results showed that after 8 weeks, serial application of BMP2 and FGF2 significantly improved the periodontal tissue regeneration, whereas application of BMP2 only showed greater new bone formation after 4 weeks. CONCLUSIONS: The serial application of BMP2 and FGF2 may have synergistic effects on periodontal tissue regeneration over time.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00008505-201710000-00005&LSLINK=80&D=ovft
DOI
10.1097/ID.0000000000000624
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hwan(김지환) ORCID logo https://orcid.org/0000-0002-0872-4906
Park, Young Bum(박영범)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161072
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