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Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits

Authors
 Jisun Huh  ;  Ui-Won Jung  ;  Kyeong-Mee Park  ;  Hyun Sil Kim  ;  Kee-Deog Kim  ;  Wonse Park 
Citation
 BioMed Research International, Vol.2017 : 6087676, 2017 
Journal Title
 BioMed Research International 
ISSN
 2314-6133 
Issue Date
2017
MeSH
Animals ; Cattle ; Cell Count ; Female ; Maxillary Sinus/diagnostic imaging ; Maxillary Sinus/pathology ; Maxillary Sinus/surgery ; Nasal Mucosa/surgery ; Organ Size ; Osteoclasts/pathology ; Parathyroid Hormone/pharmacology* ; Rabbits ; Sinus Floor Augmentation/methods* ; Wound Healing/drug effects* ; X-Ray Microtomography
Abstract
Purpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH (n = 10) or saline (n = 10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 μg/kg/day. Radiographic and histomorphometric analyses were performed. Result. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Conclusion. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161056
DOI
10.1155/2017/6087676
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
김기덕(Kim, Kee Deog)
김현실(Kim, Hyun Sil)
박원서(Park, Wonse)
정의원(Jung, Ui Won)
허지선(Huh, Jisun)
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