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Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis

Authors
 Pil-Gu Park  ;  Su Ji Jo  ;  Min Jung Kim  ;  Hyun Jeong Kim  ;  Ji Hae Lee  ;  Cheol Keun Park  ;  Hyunki Kim  ;  Kang Young Lee  ;  Hoguen Kim  ;  Jeon Han Park  ;  Seung Myung Dong  ;  Jae Myun Lee 
Citation
 ONCOTARGET , Vol.8(46) : 80325-80335, 2017 
Journal Title
 ONCOTARGET 
Issue Date
2017
Keywords
LOXL2 ; colorectal cancer ; epithelial-mesenchymal transition ; metastasis ; tissue microarray analysis
Abstract
Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker.
Files in This Item:
T201703598.pdf Download
DOI
10.18632/oncotarget.18170
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Hyun Jeong(김현정) ORCID logo https://orcid.org/0000-0002-3116-8848
Kim, Ho Keun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Park, Pil Gu(박필구) ORCID logo https://orcid.org/0000-0002-3024-3439
Lee, Kang Young(이강영)
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160917
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