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Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis

Authors
 Pil-Gu Park  ;  Su Ji Jo  ;  Min Jung Kim  ;  Hyun Jeong Kim  ;  Ji Hae Lee  ;  Cheol Keun Park  ;  Hyunki Kim  ;  Kang Young Lee  ;  Hoguen Kim  ;  Jeon Han Park  ;  Seung Myung Dong  ;  Jae Myun Lee 
Citation
 Oncotarget, Vol.8(46) : 80325-80335, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
Keywords
LOXL2 ; colorectal cancer ; epithelial-mesenchymal transition ; metastasis ; tissue microarray analysis
Abstract
Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160917
DOI
10.18632/oncotarget.18170
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김민정(Kim, Min Jung) ; 김현기(Kim, Hyunki) ; 김현정(Kim, Hyun Jeong) ; 김호근(Kim, Ho Keun) ; 박전한(Park, Jeon Han) ; 박필구(Park, Pil Gu) ; 이강영(Lee, Kang Young) ; 이재면(Lee, Jae Myun)
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