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Cited 8 times in

Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis

DC FieldValueLanguage
dc.contributor.author김현기-
dc.contributor.author김현정-
dc.contributor.author김호근-
dc.contributor.author박전한-
dc.contributor.author박필구-
dc.contributor.author이강영-
dc.contributor.author이재면-
dc.contributor.author김민정-
dc.date.accessioned2018-07-20T08:10:10Z-
dc.date.available2018-07-20T08:10:10Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160917-
dc.description.abstractColorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRole of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorPil-Gu Park-
dc.contributor.googleauthorSu Ji Jo-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorHyun Jeong Kim-
dc.contributor.googleauthorJi Hae Lee-
dc.contributor.googleauthorCheol Keun Park-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorJeon Han Park-
dc.contributor.googleauthorSeung Myung Dong-
dc.contributor.googleauthorJae Myun Lee-
dc.identifier.doi10.18632/oncotarget.18170-
dc.contributor.localIdA00472-
dc.contributor.localIdA01108-
dc.contributor.localIdA01129-
dc.contributor.localIdA01183-
dc.contributor.localIdA01641-
dc.contributor.localIdA01726-
dc.contributor.localIdA02640-
dc.contributor.localIdA03071-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid29113306-
dc.subject.keywordLOXL2-
dc.subject.keywordcolorectal cancer-
dc.subject.keywordepithelial-mesenchymal transition-
dc.subject.keywordmetastasis-
dc.subject.keywordtissue microarray analysis-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNamePark, Jeon Han-
dc.contributor.alternativeNamePark, Pil Gu-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameLee, Jae Myun-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Hyun Jeong-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorPark, Jeon Han-
dc.contributor.affiliatedAuthorPark, Pil Gu-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorLee, Jae Myun-
dc.citation.volume8-
dc.citation.number46-
dc.citation.startPage80325-
dc.citation.endPage80335-
dc.identifier.bibliographicCitationONCOTARGET , Vol.8(46) : 80325-80335, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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