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Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments

Authors
 Yoon Jin Cha  ;  Dong-Seok Kim  ;  Seung-Koo Lee  ;  Hoon-Chul Kang  ;  Se Hoon Kim 
Citation
 Brain Tumor Pathology, Vol.34(4) : 172-178, 2017 
Journal Title
 Brain Tumor Pathology 
ISSN
 1433-7398 
Issue Date
2017
MeSH
Adolescent ; Amygdala/cytology ; Amygdala/pathology* ; Antigens, Nuclear/metabolism ; Brain Neoplasms/complications* ; Brain Neoplasms/diagnosis ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology* ; Epilepsy/etiology* ; Humans ; Intermediate Filaments/pathology* ; Intermediate Filaments/ultrastructure ; Intranuclear Inclusion Bodies/pathology* ; Male ; Nerve Tissue Proteins/metabolism ; Oligodendrocyte Transcription Factor 2/metabolism ; Synaptophysin/metabolism ; Time Factors
Keywords
Brain ; Epilepsy ; Neoplasm ; Temporal lobe
Abstract
The term "long-term epilepsy-associated tumor (LEAT)" encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160854
DOI
10.1007/s10014-017-0294-8
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
강훈철(Kang, Hoon Chul) ; 김동석(Kim, Dong Seok) ; 김세훈(Kim, Se Hoon) ; 이승구(Lee, Seung Koo) ; 차윤진(Cha, Yoon Jin)
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Full Text
https://link.springer.com/article/10.1007%2Fs10014-017-0294-8
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