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Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김동석 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2018-07-20T08:07:26Z | - |
dc.date.available | 2018-07-20T08:07:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1433-7398 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160854 | - |
dc.description.abstract | The term "long-term epilepsy-associated tumor (LEAT)" encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia. Tumor cells were positive for oligodendrocyte transcription factor 2 and neuronal markers including NeuN, neurofilaments, and synaptophysin, but were negative for CD34 and nestin. The most intriguing finding was intranuclear filaments, which appeared as rod- or needle-like shapes under high-power view. Ancillary ultrastructural analysis revealed thin filamentous intranuclear structures in tumor cells. Based on the glioneuronal nature of these cells as well as the infiltrative growth pattern, a diagnosis of LEAT was rendered that was deemed WHO grade I to II; however, the clinicopathological implications of the intranuclear inclusions remain unknown. The patient is currently alive and well without seizures. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Tokyo | - |
dc.relation.isPartOf | BRAIN TUMOR PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Amygdala/cytology | - |
dc.subject.MESH | Amygdala/pathology* | - |
dc.subject.MESH | Antigens, Nuclear/metabolism | - |
dc.subject.MESH | Brain Neoplasms/complications* | - |
dc.subject.MESH | Brain Neoplasms/diagnosis | - |
dc.subject.MESH | Brain Neoplasms/metabolism | - |
dc.subject.MESH | Brain Neoplasms/pathology* | - |
dc.subject.MESH | Epilepsy/etiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intermediate Filaments/pathology* | - |
dc.subject.MESH | Intermediate Filaments/ultrastructure | - |
dc.subject.MESH | Intranuclear Inclusion Bodies/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism | - |
dc.subject.MESH | Oligodendrocyte Transcription Factor 2/metabolism | - |
dc.subject.MESH | Synaptophysin/metabolism | - |
dc.subject.MESH | Time Factors | - |
dc.title | Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.identifier.doi | 10.1007/s10014-017-0294-8 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J00397 | - |
dc.identifier.eissn | 1861-387X | - |
dc.identifier.pmid | 28799062 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10014-017-0294-8 | - |
dc.subject.keyword | Brain | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Neoplasm | - |
dc.subject.keyword | Temporal lobe | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 178 | - |
dc.identifier.bibliographicCitation | BRAIN TUMOR PATHOLOGY, Vol.34(4) : 172-178, 2017 | - |
dc.identifier.rimsid | 60738 | - |
dc.type.rims | ART | - |
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