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The association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.

 Seok-hyung Kim  ;  Donghwan Oh  ;  Kwon Soo Jung  ;  Jung Eun Lee  ;  Hyunwook Kim  ;  Hyung Jong Kim  ;  Beom Seok Kim  ;  Hyeong Cheon Park  ;  Byoung Kwon Lee  ;  Hoon Young Choi 
 PLoS One, Vol.12(9) : e0185522, 2017 
Journal Title
 PLoS One 
Issue Date
Apolipoprotein A-I/metabolism ; Apolipoproteins B/metabolism ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Female ; Humans ; Kidney/physiopathology ; Kidney Function Tests ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; ROC Curve ; Vascular Calcification/metabolism ; Vascular Calcification/pathology ; Vascular Calcification/physiopathology
BACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 determined based on the Chronic Kidney Disease -Epidemiology Collaboration equation (n  =  1,800). Mild renal insufficiency was defined as an eGFR of 60-90 mL/min/1.73 m2. Coronary artery calcification measured with computed tomography was defined as an above-zero score. Logistic regression analyses were used to determine the association between coronary calcification and the apolipoprotein B/A-I ratio according to eGFR by adjusting for the influence of confounders. RESULTS: The mean apolipoprotein B/A-I level was significantly higher in the participants with coronary artery calcification than in the participants without coronary artery calcification. The apolipoprotein B/A-I ratio was significantly different according to coronary artery calcification in the participants with normal kidney function, but in the participants with mild renal insufficiency, it was not different. After adjusting for age, male sex, systolic blood pressure, body mass index, current smoking status, and fasting plasma glucose, the apolipoprotein B/A-I ratio was significantly associated with an increased risk of coronary artery calcification in participants with normal kidney function (odds ratio = 2.411, p = 0.011), while in the participants with mild renal insufficiency, the apolipoprotein B/A-I ratio was not associated with coronary artery calcification. CONCLUSION: Our study showed that the predictive value of apolipoprotein B/A-I ratio for coronary artery calcification may differ according to kidney function.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김범석(Kim, Beom Seok) ORCID logo https://orcid.org/0000-0002-5732-2583
김석형(Kim, Seok Hyung)
김현욱(Kim, Hyun Wook)
박형천(Park, Hyeong Cheon) ORCID logo https://orcid.org/0000-0002-1550-0812
오동현(Oh, Dong Hyun)
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이정은(Lee, Jung Eun) ORCID logo https://orcid.org/0000-0003-0917-2872
정권수(Jung, Kwon Soo)
최훈영(Choi, Hoon Young)
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