0 12

Cited 0 times in

The association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.

Authors
 Seok-hyung Kim  ;  Donghwan Oh  ;  Kwon Soo Jung  ;  Jung Eun Lee  ;  Hyunwook Kim  ;  Hyung Jong Kim  ;  Beom Seok Kim  ;  Hyeong Cheon Park  ;  Byoung Kwon Lee  ;  Hoon Young Choi 
Citation
 PLoS One, Vol.12(9) : e0185522, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Apolipoprotein A-I/metabolism ; Apolipoproteins B/metabolism ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Female ; Humans ; Kidney/physiopathology ; Kidney Function Tests ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; ROC Curve ; Vascular Calcification/metabolism ; Vascular Calcification/pathology ; Vascular Calcification/physiopathology
Abstract
BACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 determined based on the Chronic Kidney Disease -Epidemiology Collaboration equation (n  =  1,800). Mild renal insufficiency was defined as an eGFR of 60-90 mL/min/1.73 m2. Coronary artery calcification measured with computed tomography was defined as an above-zero score. Logistic regression analyses were used to determine the association between coronary calcification and the apolipoprotein B/A-I ratio according to eGFR by adjusting for the influence of confounders. RESULTS: The mean apolipoprotein B/A-I level was significantly higher in the participants with coronary artery calcification than in the participants without coronary artery calcification. The apolipoprotein B/A-I ratio was significantly different according to coronary artery calcification in the participants with normal kidney function, but in the participants with mild renal insufficiency, it was not different. After adjusting for age, male sex, systolic blood pressure, body mass index, current smoking status, and fasting plasma glucose, the apolipoprotein B/A-I ratio was significantly associated with an increased risk of coronary artery calcification in participants with normal kidney function (odds ratio = 2.411, p = 0.011), while in the participants with mild renal insufficiency, the apolipoprotein B/A-I ratio was not associated with coronary artery calcification. CONCLUSION: Our study showed that the predictive value of apolipoprotein B/A-I ratio for coronary artery calcification may differ according to kidney function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160852
DOI
10.1371/journal.pone.0185522
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김범석(Kim, Beom Seok) ; 김석형(Kim, Seok Hyung) ; 김현욱(Kim, Hyun Wook) ; 박형천(Park, Hyeong Cheon) ; 오동현(Oh, Dong Hyun) ; 이병권(Lee, Byoung Kwon) ; 이정은(Lee, Jung Eun) ; 정권수(Jung, Kwon Soo) ; 최훈영(Choi, Hoon Young)
사서에게 알리기
  feedback
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse