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The association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.

 Seok-hyung Kim  ;  Donghwan Oh  ;  Kwon Soo Jung  ;  Jung Eun Lee  ;  Hyunwook Kim  ;  Hyung Jong Kim  ;  Beom Seok Kim  ;  Hyeong Cheon Park  ;  Byoung Kwon Lee  ;  Hoon Young Choi 
 PLOS ONE, Vol.12(9) : e0185522, 2017 
Journal Title
Issue Date
Apolipoprotein A-I/metabolism ; Apolipoproteins B/metabolism ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Female ; Humans ; Kidney/physiopathology ; Kidney Function Tests ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; ROC Curve ; Vascular Calcification/metabolism ; Vascular Calcification/pathology ; Vascular Calcification/physiopathology
BACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 determined based on the Chronic Kidney Disease -Epidemiology Collaboration equation (n  =  1,800). Mild renal insufficiency was defined as an eGFR of 60-90 mL/min/1.73 m2. Coronary artery calcification measured with computed tomography was defined as an above-zero score. Logistic regression analyses were used to determine the association between coronary calcification and the apolipoprotein B/A-I ratio according to eGFR by adjusting for the influence of confounders. RESULTS: The mean apolipoprotein B/A-I level was significantly higher in the participants with coronary artery calcification than in the participants without coronary artery calcification. The apolipoprotein B/A-I ratio was significantly different according to coronary artery calcification in the participants with normal kidney function, but in the participants with mild renal insufficiency, it was not different. After adjusting for age, male sex, systolic blood pressure, body mass index, current smoking status, and fasting plasma glucose, the apolipoprotein B/A-I ratio was significantly associated with an increased risk of coronary artery calcification in participants with normal kidney function (odds ratio = 2.411, p = 0.011), while in the participants with mild renal insufficiency, the apolipoprotein B/A-I ratio was not associated with coronary artery calcification. CONCLUSION: Our study showed that the predictive value of apolipoprotein B/A-I ratio for coronary artery calcification may differ according to kidney function.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Seok Hyung(김석형)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Oh, Dong Hyun(오동현)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Jung, Kwon Soo(정권수) ORCID logo https://orcid.org/0000-0003-3238-5139
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
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