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The association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.

DC FieldValueLanguage
dc.contributor.author김범석-
dc.contributor.author김석형-
dc.contributor.author김현욱-
dc.contributor.author박형천-
dc.contributor.author오동현-
dc.contributor.author이병권-
dc.contributor.author이정은-
dc.contributor.author정권수-
dc.contributor.author최훈영-
dc.date.accessioned2018-07-20T08:07:16Z-
dc.date.available2018-07-20T08:07:16Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160852-
dc.description.abstractBACKGROUND: The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population. METHODS: Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 determined based on the Chronic Kidney Disease -Epidemiology Collaboration equation (n  =  1,800). Mild renal insufficiency was defined as an eGFR of 60-90 mL/min/1.73 m2. Coronary artery calcification measured with computed tomography was defined as an above-zero score. Logistic regression analyses were used to determine the association between coronary calcification and the apolipoprotein B/A-I ratio according to eGFR by adjusting for the influence of confounders. RESULTS: The mean apolipoprotein B/A-I level was significantly higher in the participants with coronary artery calcification than in the participants without coronary artery calcification. The apolipoprotein B/A-I ratio was significantly different according to coronary artery calcification in the participants with normal kidney function, but in the participants with mild renal insufficiency, it was not different. After adjusting for age, male sex, systolic blood pressure, body mass index, current smoking status, and fasting plasma glucose, the apolipoprotein B/A-I ratio was significantly associated with an increased risk of coronary artery calcification in participants with normal kidney function (odds ratio = 2.411, p = 0.011), while in the participants with mild renal insufficiency, the apolipoprotein B/A-I ratio was not associated with coronary artery calcification. CONCLUSION: Our study showed that the predictive value of apolipoprotein B/A-I ratio for coronary artery calcification may differ according to kidney function.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApolipoprotein A-I/metabolism-
dc.subject.MESHApolipoproteins B/metabolism-
dc.subject.MESHCoronary Vessels/pathology-
dc.subject.MESHCoronary Vessels/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney/physiopathology-
dc.subject.MESHKidney Function Tests-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHROC Curve-
dc.subject.MESHVascular Calcification/metabolism-
dc.subject.MESHVascular Calcification/pathology-
dc.subject.MESHVascular Calcification/physiopathology-
dc.titleThe association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSeok-hyung Kim-
dc.contributor.googleauthorDonghwan Oh-
dc.contributor.googleauthorKwon Soo Jung-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorHyunwook Kim-
dc.contributor.googleauthorHyung Jong Kim-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorHyeong Cheon Park-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorHoon Young Choi-
dc.identifier.doi10.1371/journal.pone.0185522-
dc.contributor.localIdA00488-
dc.contributor.localIdA04526-
dc.contributor.localIdA01126-
dc.contributor.localIdA01759-
dc.contributor.localIdA02361-
dc.contributor.localIdA02793-
dc.contributor.localIdA03119-
dc.contributor.localIdA05407-
dc.contributor.localIdA04226-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28957410-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Seok Hyung-
dc.contributor.alternativeNameKim, Hyun Wook-
dc.contributor.alternativeNamePark, Hyeong Cheon-
dc.contributor.alternativeNameOh, Dong Hyun-
dc.contributor.alternativeNameLee, Byoung Kwon-
dc.contributor.alternativeNameLee, Jung Eun-
dc.contributor.alternativeNameJung, Kwon Soo-
dc.contributor.alternativeNameChoi, Hoon Young-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Seok Hyung-
dc.contributor.affiliatedAuthorKim, Hyun Wook-
dc.contributor.affiliatedAuthorPark, Hyeong Cheon-
dc.contributor.affiliatedAuthorOh, Dong Hyun-
dc.contributor.affiliatedAuthorLee, Byoung Kwon-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.contributor.affiliatedAuthorJung, Kwon Soo-
dc.contributor.affiliatedAuthorChoi, Hoon Young-
dc.citation.volume12-
dc.citation.number9-
dc.citation.startPagee0185522-
dc.identifier.bibliographicCitationPLoS One, Vol.12(9) : e0185522, 2017-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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