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The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease.

Authors
 Jae Min Shin  ;  Tae Hoon Kim  ;  Seokjin Haam  ;  Kyunghwa Han  ;  Min Kwang Byun  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Chul Hwan Park 
Citation
 PLOS ONE, Vol.12(8) : e0182849, 2017 
Journal Title
PLOS ONE
Issue Date
2017
MeSH
Adult ; Aged ; Female ; Healthy Volunteers ; Humans ; Lung/diagnostic imaging ; Lung Diseases/diagnostic imaging ; Lung Diseases, Obstructive/diagnostic imaging ; Lung Volume Measurements ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Tomography, X-Ray Computed
Abstract
In this study, we examined the repeatability of computed tomography (CT) lung volume measurements in healthy individuals and patients with obstructive and restrictive lung diseases. To do this, we retrospectively enrolled 200 healthy individuals (group 1), 100 patients with obstructive lung disease (group 2), and 100 patients with restrictive lung disease (group 3) who underwent two consecutive chest CT scans within a 1-year period. The CT lung volume was measured using a threshold-based, three-dimensional auto-segmentation technique at a default range from -200 to -1024 HU. The within-subject standard deviation, repeatability coefficient, within-subject coefficient variability, and intraclass correlation coefficient were evaluated. No significant differences were identified between the two consecutive CT lung volume measurements in any of the groups (p> 0.05). The within-subject standard deviations for groups 1, 2, and 3 were 441.1, 387.0, and 288.6, respectively, while the repeatability coefficients were 1222.6, 1072.6, and 800.1, respectively. The within-subject coefficient variabilities for groups 1, 2, and 3 were 0.097, 0.083, and 0.090, respectively, while the intraclass correlation coefficients were 0.818, 0.881, and 0.910, respectively. The two CT lung volume measurements showed excellent agreement in healthy individuals and patients with obstructive or restrictive lung disease. However, the repeatability was lower in healthy individuals than it was in patients with lung diseases.
Files in This Item:
T201703061.pdf Download
DOI
10.1371/journal.pone.0182849
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Shin, Jae Min(신재민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160695
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