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Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort

Authors
 Hye Jung Park  ;  Min Kwang Byun  ;  Hyung Jung Kim  ;  Chul Min Ahn  ;  Jin Hwa Lee  ;  Kyeong-Cheol Shin  ;  Soo-Taek Uh  ;  Seung Won Ra  ;  Kwang-Ha Yoo  ;  Ki Suck Jung 
Citation
 Allergy Asthma & Immunology Research, Vol.9(5) : 431-437, 2017 
Journal Title
 Allergy Asthma & Immunology Research 
ISSN
 2092-7355 
Issue Date
2017
Keywords
Chronic obstructive pulmonary disease ; asthma-chronic obstructive pulmonary disease overlap syndrome ; disease progression
Abstract
PURPOSE: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. METHODS: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort. The occurrence of ACO was defined as a positive response to a bronchodilator (an increase in forced expiratory volume in 1 second [FEV1] of 12% and 200 mL). RESULTS: Among 1,504 patients with COPD, 223 (14.8%) were diagnosed with ACO. Men (95.5%) and current smokers (32.9%) were more prevalent in the ACO group compared with the pure COPD group (90.5% and 25.3%, respectively; P=0.015 and P=0.026, respectively). Patients with ACO had a better quality of life (St. George's Respiratory Questionnaire for COPD score=31.0±18.0 [mean±standard deviation]) than those with pure COPD (35.3±19.1) (P=0.002). Although the prevalence of acute exacerbation was not different between the 2 groups, patients with severe exacerbation required hospital admission significantly more frequently in the pure COPD group than in the ACO group. Patients with ACO showed a higher likelihood of FEV1 recovery than those with pure COPD (P<0.001). CONCLUSIONS: We suggest that ACO is characterized by less severe symptoms, and therefore it might lead to rare severe exacerbation and the possibility of lung function recovery.
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DOI
10.4168/aair.2017.9.5.431
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
안철민(Ahn, Chul Min)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160493
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