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Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort

DC Field Value Language
dc.contributor.author김형중-
dc.contributor.author박혜정-
dc.contributor.author변민광-
dc.contributor.author안철민-
dc.date.accessioned2018-07-20T07:45:29Z-
dc.date.available2018-07-20T07:45:29Z-
dc.date.issued2017-
dc.identifier.issn2092-7355-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160493-
dc.description.abstractPURPOSE: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. METHODS: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort. The occurrence of ACO was defined as a positive response to a bronchodilator (an increase in forced expiratory volume in 1 second [FEV1] of 12% and 200 mL). RESULTS: Among 1,504 patients with COPD, 223 (14.8%) were diagnosed with ACO. Men (95.5%) and current smokers (32.9%) were more prevalent in the ACO group compared with the pure COPD group (90.5% and 25.3%, respectively; P=0.015 and P=0.026, respectively). Patients with ACO had a better quality of life (St. George's Respiratory Questionnaire for COPD score=31.0±18.0 [mean±standard deviation]) than those with pure COPD (35.3±19.1) (P=0.002). Although the prevalence of acute exacerbation was not different between the 2 groups, patients with severe exacerbation required hospital admission significantly more frequently in the pure COPD group than in the ACO group. Patients with ACO showed a higher likelihood of FEV1 recovery than those with pure COPD (P<0.001). CONCLUSIONS: We suggest that ACO is characterized by less severe symptoms, and therefore it might lead to rare severe exacerbation and the possibility of lung function recovery.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.publisherKorean Academy of Pediatric Allergy and Respiratory Disease-
dc.relation.isPartOfALLERGY ASTHMA & IMMUNOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAsthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorMin Kwang Byun-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorChul Min Ahn-
dc.contributor.googleauthorJin Hwa Lee-
dc.contributor.googleauthorKyeong-Cheol Shin-
dc.contributor.googleauthorSoo-Taek Uh-
dc.contributor.googleauthorSeung Won Ra-
dc.contributor.googleauthorKwang-Ha Yoo-
dc.contributor.googleauthorKi Suck Jung-
dc.identifier.doi10.4168/aair.2017.9.5.431-
dc.contributor.localIdA01158-
dc.contributor.localIdA01769-
dc.contributor.localIdA01848-
dc.contributor.localIdA02269-
dc.relation.journalcodeJ00064-
dc.identifier.eissn2092-7363-
dc.identifier.pmid28677357-
dc.subject.keywordChronic obstructive pulmonary disease-
dc.subject.keywordasthma-chronic obstructive pulmonary disease overlap syndrome-
dc.subject.keyworddisease progression-
dc.contributor.alternativeNameKim, Hyung Jung-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameByun, Min Kwang-
dc.contributor.alternativeNameAhn, Chul Min-
dc.contributor.affiliatedAuthorKim, Hyung Jung-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorByun, Min Kwang-
dc.contributor.affiliatedAuthorAhn, Chul Min-
dc.citation.volume9-
dc.citation.number5-
dc.citation.startPage431-
dc.citation.endPage437-
dc.identifier.bibliographicCitationALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.9(5) : 431-437, 2017-
dc.identifier.rimsid43091-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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