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Reassessment of alkaline phosphatase as serum tumor marker with high specificity in osteosarcoma

Authors
 Seung Hyun Kim  ;  Kyoo‐Ho Shin  ;  Seong‐Hwan Moon  ;  Jinyoung Jang  ;  Hyo Song Kim  ;  Jin‐Suck Suh  ;  Woo‐Ick Yang 
Citation
 Cancer Medicine, Vol.6(6) : 1311-1322, 2017 
Journal Title
 Cancer Medicine 
Issue Date
2017
MeSH
Adolescent ; Alkaline Phosphatase/blood* ; Biomarkers, Tumor/blood* ; Bone Neoplasms/blood* ; Bone Neoplasms/diagnosis ; Bone Neoplasms/pathology ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Osteosarcoma/blood* ; Osteosarcoma/diagnosis ; Osteosarcoma/pathology ; Sensitivity and Specificity ; Tumor Burden
Keywords
Alkaline Phosphatase ; High specificity ; Osteosarcoma ; Serum Tumor Marker
Abstract
The goal of this study was to reassess serum alkaline phosphatase (ALP) as tumor marker in osteosarcoma. We retrospectively examined serum ALP levels at diagnosis, every therapeutic step (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy), metastasis, and follow-up and analyzed the role of ALP as tumor marker in 210 osteosarcomas. The diagnostic performances of ALP were validated with pathology-proven 899 other primary bone lesions. Elevated ALP at diagnosis was associated with inferior overall survival (OS) (Log Rank P < 0.001) and disease-free survival (Log Rank P = 0.005) and independently significant for OS in multivariate analysis (hazard ratio [HR]=2.12, P = 0.032). During therapy, the ALP level significantly changed according to therapeutic steps (P < 0.001 for patients ≥15 years old, P < 0.001 for patients <15 years old) and survival (P = 0.015 for ≥15 years, P = 0.002 for <15 years), and the response of ALP to therapy and survival were associated (P = 0.042 for ≥15 years, P = 0.036 for <15 years). Initial ALP level was linearly correlated with tumor burden (total tumor volume; P = 0.016 for ≥15 years, bone tumor volume; P = 0.012 for ≥15 years). The sensitivity and specificity of ALP on diagnosis were 53.2% (95% Confidence Interval [CI]: 0.475-0.586) and 90.1% (95% CI: 0.888-0.913). The sensitivity of ALP on metastasis was 53.2% (95% CI: 0.431-0.624), and the specificity was 78.2% (95% CI: 0.720-0.839) at15 months postoperative and 90.0% (95% CI: 0.824-0.952) at 3 years postoperative. Serum ALP was found to be a valuable tumor marker with high specificity in osteosarcoma.
Files in This Item:
T201702075.pdf Download
DOI
10.1002/cam4.1022
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Hyun(김승현) ORCID logo https://orcid.org/0000-0002-3878-1944
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Moon, Seong Hwan(문성환)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Shin, Kyoo Ho(신규호)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Jang, Jin Young(장진영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160311
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