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Usefulness of the delta neutrophil index as an ancillary test in the emergency department for the early diagnosis of suspected acute promyelocytic leukemia

 Dong Ryul Ko  ;  Ji Eun Jang  ;  Sung Phil Chung  ;  Jong Wook Lee  ;  Hye Sun Lee  ;  Jung Hwa Hong  ;  Taeyoung Kong  ;  Je Sung You  ;  Incheol Park 
 Leukemia & Lymphoma, Vol.58(10) : 2387-2394, 2017 
Journal Title
 Leukemia & Lymphoma 
Issue Date
Acute myeloid leukemia ; acute promyelocytic leukemia ; delta neutrophil index ; diagnosis ; disseminated intravascular coagulopathy ; predictive value
The delta neutrophil index (DNI) reflects the fraction of circulating immature granulocytes. We evaluated the usefulness of DNI values in patients with acute myeloid leukemia (AML) to distinguish the acute stage of acute promyelocytic leukemia (APL). We analyzed patients retrospectively who were first diagnosed with AML upon admission to the emergency department (ED). Thirty of the 134 patients (22.4%) were diagnosed with APL on ED admission. The univariate analysis and multivariate logistic regression models revealed that DNI values differed significantly between APL and non-APL AML patients on days 0, 1 and 2. Increased predictability for APL was associated with a DNI greater than 24.2% on ED admission, greater than 23.6% on day 1 and greater than 44% on day 2 in patients with AML. DNI values of patients with AML could discriminate the acute stage of APL from AML for immediate initiation of all-trans retinoic acid therapy.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
고동률(Ko, Dong Ryul) ORCID logo https://orcid.org/0000-0002-3098-2784
공태영(Kong, Tae Young) ORCID logo https://orcid.org/0000-0002-4182-7245
박인철(Park, In Cheol) ORCID logo https://orcid.org/0000-0001-7033-766X
유제성(You, Je Sung) ORCID logo https://orcid.org/0000-0002-2074-6745
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
장지은(Jang, Ji Eun) ORCID logo https://orcid.org/0000-0001-8832-1412
정성필(Chung, Sung Pil) ORCID logo https://orcid.org/0000-0002-3074-011X
홍정화(Hong, Jung Hwa)
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