257 440

Cited 29 times in

Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease

 Chansik An  ;  Youn Ah Choi  ;  Dongil Choi  ;  Yong Han Paik  ;  Sang Hoon Ahn  ;  Myeong-Jin Kim  ;  Seung Woon Paik  ;  Kwang-Hyub Han  ;  Mi-Suk Park 
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.21(3) : 279-286, 2015 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology* ; Demography ; Female ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/drug therapy ; Hepatitis C, Chronic/complications* ; Hepatitis C, Chronic/drug therapy ; Humans ; Linear Models ; Liver Neoplasms/complications ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Staging ; Republic of Korea ; Retrospective Studies ; Tertiary Care Centers ; Tomography, X-Ray Computed
Follow-up studies ; Hepatocellular carcinoma ; Liver neoplasm ; Surveillance ; Tumor burden
BACKGROUND/AIMS: The goal of this study was to estimate the growth rate of hepatocellular carcinoma (HCC) and identify the host factors that significantly affect this rate.

METHODS: Patients with early-stage HCC (n=175) who underwent two or more serial dynamic imaging studies without any anticancer treatment at two tertiary care hospitals in Korea were identified. For each patient, the tumor volume doubling time (TVDT) of HCC was calculated by comparing tumor volumes between serial imaging studies. Clinical and laboratory data were obtained from the medical records of the patients.

RESULTS: The median TVDT was 85.7 days, with a range of 11 to 851.2 days. Multiple linear regression revealed that the initial tumor diameter (a tumor factor) and the etiology of chronic liver disease (a host factor) were significantly associated with the TVDT. The TVDT was shorter when the initial tumor diameter was smaller, and was shorter in HCC related to hepatitis B virus (HBV) infection than in HCC related to hepatitis C virus (HCV) infection (median, 76.8 days vs. 137.2 days; P=0.0234).

CONCLUSIONS: The etiology of chronic liver disease is a host factor that may significantly affect the growth rate of early-stage HCC, since HBV-associated HCC grows faster than HCV-associated HCC.
Files in This Item:
T201506053.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
An, Chansik(안찬식) ORCID logo https://orcid.org/0000-0002-0484-6658
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.