Cited 61 times in
Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 안찬식 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2018-03-26T17:07:26Z | - |
dc.date.available | 2018-03-26T17:07:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157218 | - |
dc.description.abstract | BACKGROUND/AIMS: The goal of this study was to estimate the growth rate of hepatocellular carcinoma (HCC) and identify the host factors that significantly affect this rate. METHODS: Patients with early-stage HCC (n=175) who underwent two or more serial dynamic imaging studies without any anticancer treatment at two tertiary care hospitals in Korea were identified. For each patient, the tumor volume doubling time (TVDT) of HCC was calculated by comparing tumor volumes between serial imaging studies. Clinical and laboratory data were obtained from the medical records of the patients. RESULTS: The median TVDT was 85.7 days, with a range of 11 to 851.2 days. Multiple linear regression revealed that the initial tumor diameter (a tumor factor) and the etiology of chronic liver disease (a host factor) were significantly associated with the TVDT. The TVDT was shorter when the initial tumor diameter was smaller, and was shorter in HCC related to hepatitis B virus (HBV) infection than in HCC related to hepatitis C virus (HCV) infection (median, 76.8 days vs. 137.2 days; P=0.0234). CONCLUSIONS: The etiology of chronic liver disease is a host factor that may significantly affect the growth rate of early-stage HCC, since HBV-associated HCC grows faster than HCV-associated HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association for the Study of the Liver | - |
dc.relation.isPartOf | CLINICAL AND MOLECULAR HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antiviral Agents/therapeutic use | - |
dc.subject.MESH | Carcinoma, Hepatocellular/complications | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.MESH | Demography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Hepatitis B, Chronic/drug therapy | - |
dc.subject.MESH | Hepatitis C, Chronic/complications* | - |
dc.subject.MESH | Hepatitis C, Chronic/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Liver Neoplasms/complications | - |
dc.subject.MESH | Liver Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Chansik An | - |
dc.contributor.googleauthor | Youn Ah Choi | - |
dc.contributor.googleauthor | Dongil Choi | - |
dc.contributor.googleauthor | Yong Han Paik | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Seung Woon Paik | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.identifier.doi | 10.3350/cmh.2015.21.3.279 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02268 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J00557 | - |
dc.identifier.eissn | 2287-285X | - |
dc.identifier.pmid | 26523271 | - |
dc.subject.keyword | Follow-up studies | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Liver neoplasm | - |
dc.subject.keyword | Surveillance | - |
dc.subject.keyword | Tumor burden | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | An, Chan Sik | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | An, Chan Sik | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 279 | - |
dc.citation.endPage | 286 | - |
dc.identifier.bibliographicCitation | CLINICAL AND MOLECULAR HEPATOLOGY, Vol.21(3) : 279-286, 2015 | - |
dc.identifier.rimsid | 41778 | - |
dc.type.rims | ART | - |
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