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Biologic Response of Human Deciduous Dental Pulp Cells on Newly Developed MTA-like Materials

Other Titles
 새로 개발된 MTA 유사 재료에 대한 유치 치수세포의 생물학적 반응 
 Haewon Lee  ;  Yooseok Shin  ;  Jaeeun Jung  ;  Seongoh Kim  ;  Jaeho Lee  ;  Jeseon Song 
 Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지), Vol.42(4) : 291-301, 2015 
Journal Title
Journal of the Korean Academy of Pediatric Dentistry(대한소아치과학회지)
Issue Date
Mineral trioxide aggregate ; Human dental pulp cells ; Cell viability ; Differentiation
This study compared the in vitro cell viability and differentiation potentials of human deciduous dental pulp cells (DPCs) on mineral trioxide aggregate (MTA)-like products (ProRoot MTA, RetroMTA and Endocem Zr). The experimental materials were prepared as circular discs, which were used to test the effects of the materials on the viability of human DPCs when placed in direct and indirect contact. Furthermore, the pH of the extracted materials was recorded, and their effect on cell differentiation potential was evaluated by evaluating the alkaline phosphatase (ALP) activity and Alizarin Red S staining of DPCs incubated with the test materials. In direct contact, the cell viability of human DPCs was higher with ProRoot MTA and RetroMTA than with Endocem Zr. However, when in indirect contact, the cell viability of human DPCs was generally higher in Endocem Zr than in ProRoot MTA and Retro MTA. With respect to pH, the alkalinity was lower for Endocem Zr than for the other test materials. The ALP activities of the cells were not enhanced by any of the experimental materials. Alizarin Red S staining of the tested human DPCs revealed that their differentiation potential was lower than for cells incubated with osteogenic induction medium. While there were differences in the responses of the human DPCs to the test materials, all displayed degrees of cytotoxicity and were unable to enhance either the viability or differentiation of human DPCs. However, Endocem Zr exhibited better cell viability and was less alkaline than the other test materials.
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Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Oh(김성오) ORCID logo https://orcid.org/0000-0002-8620-1377
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Shin, Yoo Seok(신유석) ORCID logo https://orcid.org/0000-0003-1121-2570
Lee, Jae Ho(이제호) ORCID logo https://orcid.org/0000-0002-1556-3485
Lee, Hae Won(이혜원)
Jung, Jae Eun(정재은)
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