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Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses.

Authors
 Jong-Seok Kim  ;  Woo Sik Kim  ;  Hong-Hee Choi  ;  Hong Min Kim  ;  Kee Woong Kwon  ;  Seung Jung Han  ;  Seung Bin Cha  ;  Sang-Nae Cho  ;  Won-Jung Koh  ;  Sung Jae Shin 
Citation
 CELLULAR IMMUNOLOGY, Vol.298(1-2) : 115-125, 2015 
Journal Title
 CELLULAR IMMUNOLOGY 
ISSN
 0008-8749 
Issue Date
2015
MeSH
Animals ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Cells, Cultured ; Dendritic Cells/immunology* ; Female ; Interferon-gamma/secretion ; Interleukin-2/secretion ; Lymphocyte Activation/immunology ; MAP Kinase Signaling System/immunology ; Methylmalonate-Semialdehyde Dehydrogenase (Acylating)/immunology* ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism* ; Mycobacterium tuberculosis/immunology* ; NF-kappa B/metabolism* ; Th1 Cells/immunology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/microbiology
Keywords
Dendritic cells ; MAP kinase ; MmsA ; Mycobacterium tuberculosis ; Th1-type immunity
Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is an outstanding pathogen that modulates the host immune response. This inconvenient truth drives the continual identification of antigens that generate protective immunity, including Th1-type T cell immunity. Here, the contribution of methylmalonate semialdehyde dehydrogenase (MmsA, Rv0753c) of Mtb to immune responses was examined in the context of dendritic cell (DC) activation and T cell immunity both in vitro and in vivo. The results showed that MmsA induced DC activation by activating the MAPK and NF-κB signaling pathways. Additionally, MmsA-treated DCs activated naïve T cells, effectively polarized CD4(+) and CD8(+) T cells to secrete IFN-γ and IL-2, and induced T cell proliferation. These results indicate that MmsA is a novel DC maturation-inducing antigen that drives the Th1 immune response. Thus, MmsA was found to potentially regulate immune responses via DC activation toward Th1-type T cell immunity, enhancing our understanding of Mtb pathogenesis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0008874915300290
DOI
10.1016/j.cellimm.2015.10.005
Appears in Collections:
5. Research Institutes (연구소) > Institute for Immunology and Immunological Disease (면역질환연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Seok(김종석)
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
Cho, Sang Nae(조상래)
Cha, Seung Bin(차승빈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156825
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