Cited 14 times in
Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종석 | - |
dc.contributor.author | 신성재 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 차승빈 | - |
dc.date.accessioned | 2018-03-26T16:47:48Z | - |
dc.date.available | 2018-03-26T16:47:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156825 | - |
dc.description.abstract | Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is an outstanding pathogen that modulates the host immune response. This inconvenient truth drives the continual identification of antigens that generate protective immunity, including Th1-type T cell immunity. Here, the contribution of methylmalonate semialdehyde dehydrogenase (MmsA, Rv0753c) of Mtb to immune responses was examined in the context of dendritic cell (DC) activation and T cell immunity both in vitro and in vivo. The results showed that MmsA induced DC activation by activating the MAPK and NF-κB signaling pathways. Additionally, MmsA-treated DCs activated naïve T cells, effectively polarized CD4(+) and CD8(+) T cells to secrete IFN-γ and IL-2, and induced T cell proliferation. These results indicate that MmsA is a novel DC maturation-inducing antigen that drives the Th1 immune response. Thus, MmsA was found to potentially regulate immune responses via DC activation toward Th1-type T cell immunity, enhancing our understanding of Mtb pathogenesis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | CELLULAR IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Bacterial/immunology | - |
dc.subject.MESH | Bacterial Proteins/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dendritic Cells/immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Interferon-gamma/secretion | - |
dc.subject.MESH | Interleukin-2/secretion | - |
dc.subject.MESH | Lymphocyte Activation/immunology | - |
dc.subject.MESH | MAP Kinase Signaling System/immunology | - |
dc.subject.MESH | Methylmalonate-Semialdehyde Dehydrogenase (Acylating)/immunology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Th1 Cells/immunology | - |
dc.subject.MESH | Tuberculosis, Pulmonary/immunology | - |
dc.subject.MESH | Tuberculosis, Pulmonary/microbiology | - |
dc.title | Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses. | - |
dc.type | Article | - |
dc.contributor.college | Research Institutes | - |
dc.contributor.department | Institute for Immunology and Immunological Disease | - |
dc.contributor.googleauthor | Jong-Seok Kim | - |
dc.contributor.googleauthor | Woo Sik Kim | - |
dc.contributor.googleauthor | Hong-Hee Choi | - |
dc.contributor.googleauthor | Hong Min Kim | - |
dc.contributor.googleauthor | Kee Woong Kwon | - |
dc.contributor.googleauthor | Seung Jung Han | - |
dc.contributor.googleauthor | Seung Bin Cha | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Won-Jung Koh | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.1016/j.cellimm.2015.10.005 | - |
dc.contributor.localId | A00920 | - |
dc.contributor.localId | A02114 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A03998 | - |
dc.relation.journalcode | J00498 | - |
dc.identifier.eissn | 1090-2163 | - |
dc.identifier.pmid | 26507911 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0008874915300290 | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | MAP kinase | - |
dc.subject.keyword | MmsA | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | Th1-type immunity | - |
dc.contributor.alternativeName | Kim, Jong Seok | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Cha, Seung Bin | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seok | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cha, Seung Bin | - |
dc.citation.volume | 298 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 125 | - |
dc.identifier.bibliographicCitation | CELLULAR IMMUNOLOGY, Vol.298(1-2) : 115-125, 2015 | - |
dc.identifier.rimsid | 39953 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.