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Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis

Authors
 HYUNG SEOK LEE  ;  HYE SUN LEE  ;  HYO EUN LEE  ;  MI KYUNG BAE  ;  KYUNG YOUNG CHUNG  ;  HA YOUNG SHIN  ;  YOUNG-CHUL CHOI  ;  SEUNG MIN KIM 
Citation
 MUSCLE & NERVE, Vol.52(2) : 216-220, 2015 
Journal Title
 MUSCLE & NERVE 
ISSN
 0148-639X 
Issue Date
2015
MeSH
Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Myasthenia Gravis/diagnosis* ; Myasthenia Gravis/surgery* ; Postoperative Complications/diagnosis* ; Postoperative Complications/etiology ; Predictive Value of Tests ; Retrospective Studies ; Thymectomy/adverse effects* ; Thymectomy/trends ; Video-Assisted Surgery/adverse effects* ; Video-Assisted Surgery/trends ; Young Adult
Keywords
myasthenia gravis ; myasthenic crisis ; prognosis ; thymectomy ; videoscopic thymectomy
Abstract
INTRODUCTION: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). METHODS: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. RESULTS: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P < 0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P = 0.001) and nasalis muscles (54.1% vs. 21.4%, P < 0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P = 0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P = 0.044) were independently associated with MCAVT. CONCLUSIONS: FVC and decremental response of orbicularis oculi were associated with MCAVT.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mus.24531/abstract
DOI
10.1002/mus.24531
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Bae, Mi Kyung(배미경)
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Lee, Hyung Seok(이형석)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Lee, Hyo Eun(이효은)
Chung, Kyung Young(정경영)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156753
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