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MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization

 Seungsoo Lee  ;  Kyung Ah Kim  ;  Mi-Suk Park  ;  Sun Young Choi 
 Journal of Korean Medical Science, Vol.30(7) : 965-973, 2015 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use* ; Carcinoma, Hepatocellular/drug therapy* ; Chemoembolization, Therapeutic* ; Disease Progression ; Drug Carriers/pharmacology* ; Female ; Humans ; Liver Neoplasms/drug therapy* ; Magnetic Resonance Imaging ; Male ; Microspheres ; Middle Aged ; Multidetector Computed Tomography ; Treatment Outcome
Carcinoma, Hepatocellular ; Drug-eluting Beads ; Magnetic Resonance Imaging ; Subtraction Image ; Transcatheter Arterial Chemoembolization
The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P=0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Lee, Seung Soo(이승수)
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