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MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization

DC FieldValueLanguage
dc.contributor.author박미숙-
dc.contributor.author이승수-
dc.date.accessioned2018-03-26T16:41:15Z-
dc.date.available2018-03-26T16:41:15Z-
dc.date.issued2015-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156714-
dc.description.abstractThe purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P=0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents/administration & dosage-
dc.subject.MESHAntineoplastic Agents/therapeutic use*-
dc.subject.MESHCarcinoma, Hepatocellular/drug therapy*-
dc.subject.MESHChemoembolization, Therapeutic*-
dc.subject.MESHDisease Progression-
dc.subject.MESHDrug Carriers/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/drug therapy*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMicrospheres-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultidetector Computed Tomography-
dc.subject.MESHTreatment Outcome-
dc.titleMRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorSeungsoo Lee-
dc.contributor.googleauthorKyung Ah Kim-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorSun Young Choi-
dc.identifier.doi10.3346/jkms.2015.30.7.965-
dc.contributor.localIdA01463-
dc.contributor.localIdA05261-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid26130962-
dc.subject.keywordCarcinoma, Hepatocellular-
dc.subject.keywordDrug-eluting Beads-
dc.subject.keywordMagnetic Resonance Imaging-
dc.subject.keywordSubtraction Image-
dc.subject.keywordTranscatheter Arterial Chemoembolization-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNameLee, Seung Soo-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorLee, Seung Soo-
dc.citation.volume30-
dc.citation.number7-
dc.citation.startPage965-
dc.citation.endPage973-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.30(7) : 965-973, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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