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Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism

Authors
 Seung Ha Lee  ;  Han Kyeol Kim  ;  Young Gun Lee  ;  Chul Hyoung Lyoo  ;  Sung Jun Ahn  ;  Myung Sik Lee 
Citation
 Journal of Movement Disorders, Vol.10(1) : 35-39, 2017 
Journal Title
 Journal of Movement Disorders 
ISSN
 2093-4939 
Issue Date
2017
Keywords
Drug-induced parkinsonism ; dopamine transporter ; hyposmia ; positron-emission tomography
Abstract
Objective : Patients with drug-induced parkinsonism (DIP) may have nigrostriatal dopaminergic degeneration. We studied the clinical features that may indicate nigrostriatal dopaminergic degeneration in patients with DIP. Methods : Forty-one DIP patients were classified into normal and abnormal [18F] FP-CIT scan groups. Differences in 32 clinical features and drug withdrawal effects were studied. Results : Twenty-eight patients had normal (Group I) and 13 patients had abnormal (Group II) scans. Eight patients of Group I, but none of Group II, had taken calcium channel blockers (p = 0.040). Three patients of Group I and six of Group II had hyposmia (p = 0.018). After drug withdrawal, Group I showed greater improvement in Unified Parkinson’s Disease Rating Scale total motor scores and subscores for bradykinesia and tremors than Group II. Only hyposmia was an independent factor associated with abnormal scans, but it had suboptimal sensitivity. Conclusion : None of the clinical features were practical indicators of nigrostriatal dopaminergic degeneration in patients with DIP.
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DOI
10.14802/jmd.16045
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Seung Ha(이승하)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154705
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