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Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study

 Zixin Deng  ;  Zhaoyang Fan  ;  Sang-Eun Lee  ;  Christopher Nguyen  ;  Yibin Xie  ;  Jianing Pang  ;  Xiaoming Bi  ;  Qi Yang  ;  Byoung-Wook Choi  ;  Jung-Sun Kim  ;  Daniel Berman  ;  Hyuk-Jae Chang  ;  Debiao Li 
 Magnetic Resonance in Medicine, Vol.77(2) : 529-537, 2017 
Journal Title
 Magnetic Resonance in Medicine 
Issue Date
Aged ; Blood Flow Velocity* ; Blood Pressure* ; Blood Pressure Determination ; Coronary Stenosis/diagnostic imaging* ; Coronary Stenosis/physiopathology* ; Feasibility Studies ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods* ; Magnetic Resonance Angiography/methods* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Vascular Resistance
coronary artery disease (CAD) ; coronary pressure gradient ; fractional flow reserve (FFR) ; magnetic resonance imaging (MRI) ; phase-contrast MRI (PC-MRI) ; relative pressure difference estimation
PURPOSE: To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. METHODS: Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔPMR ) and that obtained using pressure transducer (ΔPPT ) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔPMR measurement across a coronary stenosis. RESULTS: Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔPMR vs ΔPPT ) was observed: intraclass correlation (ICC) of 0.95(Vz ), 0.72(Vx ), 0.73(Vy ), and 0.87(ΔPMR ) and R2  = 0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(Vz ), 0.76/0.74(Vx ), and 0.80/0.77(Vy ) at cardiac phase 1/2. Significant (p = 0.025) increase in ΔPMR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). CONCLUSION: ΔPMR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔPMR has the potential for noninvasive assessment of coronary artery stenosis. Magn Reson Med 77:529-537, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0001-6645-4038
Chang, Hyuck Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
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