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Association between HbA1c and carotid atherosclerosis among elderly Koreans with normal fasting glucose

 Seung Won Lee  ;  Hyeon Chang Kim  ;  Yong-ho Lee  ;  Bo Mi Song  ;  Hansol Choi  ;  Ji Hye Park  ;  Yumie Rhee  ;  Chang Oh Kim 
 PLoS One, Vol.12(2) : e0171761, 2017 
Journal Title
 PLoS One 
Issue Date
Aged ; Aged, 80 and over ; Blood Glucose* ; Carotid Artery Diseases/blood* ; Carotid Artery Diseases/epidemiology* ; Carotid Artery Diseases/pathology ; Carotid Intima-Media Thickness ; Fasting/blood* ; Female ; Glycated Hemoglobin A* ; Humans ; Male ; Public Health Surveillance ; Republic of Korea/epidemiology ; Surveys and Questionnaires
AIM: We examined whether glycated haemoglobin (HbA1c) is associated to carotid atherosclerosis in an elderly Korean population with normal fasting glucose. METHODS: Using data from the Korean Urban Rural Elderly study, we conducted a cross-sectional analysis of 1,133 participants (335 men and 798 women) with a mean age of 71.8 years. All participants had fasting blood glucose less than 100mg/dL (5.6 mmol/L) and HbA1c level below 6.5% (48 mmol/mol). They were also free from a history of cardiovascular disease, known type 2 diabetes mellitus or use of anti-diabetes medications. Carotid atherosclerosis was assessed by intima-media thickness (IMT) using ultrasonography. The association between HbA1c and carotid IMT was investigated using multivariable linear regression analysis. RESULTS: HbA1c levels were independently and positively associated with carotid IMT (β = 0.020, p = 0.045) after adjusting for sex, age, body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, LDL cholesterol, smoking and alcohol intake. However, fasting insulin and glucose levels were not associated with carotid IMT. CONCLUSION: HbA1c levels were positively associated with carotid atherosclerosis, as assessed by carotid IMT, in an elderly population with normoglycemia. Our study suggested that higher HbA1c level is an effective and informative marker of carotid atherosclerosis in an elderly population.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
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