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Association between HbA1c and carotid atherosclerosis among elderly Koreans with normal fasting glucose

DC Field Value Language
dc.contributor.author김창오-
dc.contributor.author김현창-
dc.contributor.author이용호-
dc.contributor.author이유미-
dc.date.accessioned2017-11-02T08:36:14Z-
dc.date.available2017-11-02T08:36:14Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154663-
dc.description.abstractAIM: We examined whether glycated haemoglobin (HbA1c) is associated to carotid atherosclerosis in an elderly Korean population with normal fasting glucose. METHODS: Using data from the Korean Urban Rural Elderly study, we conducted a cross-sectional analysis of 1,133 participants (335 men and 798 women) with a mean age of 71.8 years. All participants had fasting blood glucose less than 100mg/dL (5.6 mmol/L) and HbA1c level below 6.5% (48 mmol/mol). They were also free from a history of cardiovascular disease, known type 2 diabetes mellitus or use of anti-diabetes medications. Carotid atherosclerosis was assessed by intima-media thickness (IMT) using ultrasonography. The association between HbA1c and carotid IMT was investigated using multivariable linear regression analysis. RESULTS: HbA1c levels were independently and positively associated with carotid IMT (β = 0.020, p = 0.045) after adjusting for sex, age, body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, LDL cholesterol, smoking and alcohol intake. However, fasting insulin and glucose levels were not associated with carotid IMT. CONCLUSION: HbA1c levels were positively associated with carotid atherosclerosis, as assessed by carotid IMT, in an elderly population with normoglycemia. Our study suggested that higher HbA1c level is an effective and informative marker of carotid atherosclerosis in an elderly population.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBlood Glucose*-
dc.subject.MESHCarotid Artery Diseases/blood*-
dc.subject.MESHCarotid Artery Diseases/epidemiology*-
dc.subject.MESHCarotid Artery Diseases/pathology-
dc.subject.MESHCarotid Intima-Media Thickness-
dc.subject.MESHFasting/blood*-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPublic Health Surveillance-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSurveys and Questionnaires-
dc.titleAssociation between HbA1c and carotid atherosclerosis among elderly Koreans with normal fasting glucose-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSeung Won Lee-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorBo Mi Song-
dc.contributor.googleauthorHansol Choi-
dc.contributor.googleauthorJi Hye Park-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorChang Oh Kim-
dc.identifier.doi10.1371/journal.pone.0171761-
dc.contributor.localIdA01142-
dc.contributor.localIdA02989-
dc.contributor.localIdA03012-
dc.contributor.localIdA01044-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28178313-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.citation.titlePLoS One-
dc.citation.volume12-
dc.citation.number2-
dc.citation.startPagee0171761-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(2) : e0171761, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43723-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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