%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Seung Won Lee, Hyeon Chang Kim, Yong-ho Lee, Bo Mi Song, Hansol Choi, Ji Hye Park, Yumie Rhee, Chang Oh Kim
Association between HbA1c and carotid atherosclerosis among elderly Koreans with normal fasting glucose
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref005)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref006)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref007)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref009)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref010)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref012)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref013)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref016)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref017)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref018)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref009)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref007)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref008)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref007)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref008)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref019)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref020)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref019)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref021)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0171761.ref022)>>
endobj
14 0 obj
[37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
endobj
37 0 obj
<>stream
q
0.83 0.64 0.02 0 k
219.685 662.0031 m
224.3339 662.0031 l
h
f*
393.4488 649.0205 m
398.0976 649.0205 l
h
f*
403.1433 649.0205 m
407.7354 649.0205 l
h
f*
442.0346 635.9811 m
446.6835 635.9811 l
h
f*
535.8047 622.9984 m
540.4535 622.9984 l
h
f*
545.4992 622.9984 m
550.148 622.9984 l
h
f*
359.5465 596.9764 m
368.8441 596.9764 l
h
f*
373.8898 596.9764 m
383.1307 596.9764 l
h
f*
495.1559 583.9937 m
504.4535 583.9937 l
h
f*
509.4992 583.9937 m
518.7969 583.9937 l
h
f*
386.4189 558.0283 m
395.6598 558.0283 l
h
f*
397.8142 558.0283 m
407.1118 558.0283 l
h
f*
453.8268 544.989 m
458.4756 544.989 l
h
f*
534.2173 532.0063 m
538.8661 532.0063 l
h
f*
541.0205 532.0063 m
545.6126 532.0063 l
h
f*
427.2945 519.0236 m
431.8866 519.0236 l
h
f*
434.0409 519.0236 m
438.6898 519.0236 l
h
f*
389.537 391.6346 m
399.0614 391.6346 l
h
f*
401.2724 391.6346 m
410.7969 391.6346 l
h
f*
227.6787 81.9213 m
237.2031 81.9213 l
h
f*
239.4709 81.9213 m
248.9953 81.9213 l
h
f*
251.263 81.9213 m
260.7307 81.9213 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F7 1 Tf
1 TL
-0.016 Tc
0 0 Td
(Glycated)Tj
3.6453 0 Td
(hemoglobin)Tj
4.9209 0 Td
(\(HbA1c\))Tj
3.6737 0 Td
(is)Tj
0.822 0 Td
(an)Tj
1.1792 0 Td
(well-known)Tj
4.8359 0 Td
(indicator)Tj
3.7587 0 Td
(used)Tj
2.0126 0 Td
(to)Tj
0.9978 0 Td
(assess)Tj
2.4491 0 Td
(long-term)Tj
4.1442 0 Td
(control)Tj
3.0388 0 Td
(of)Tj
-35.4782 -1.3039 Td
(diabetes,)Tj
3.5773 0 Td
(and)Tj
1.6951 0 Td
(HbA1c)Tj
3.016 0 Td
(level)Tj
1.9559 0 Td
(has)Tj
1.508 0 Td
(been)Tj
2.075 0 Td
(used)Tj
2.0126 0 Td
(as)Tj
0.9864 0 Td
(a)Tj
0.6463 0 Td
(diagnostic)Tj
4.1952 0 Td
(or)Tj
1.0772 0 Td
(screening)Tj
3.9458 0 Td
(tool)Tj
1.7291 0 Td
(for)Tj
1.3493 0 Td
(type)Tj
1.8652 0 Td
(2)Tj
0.686 0 Td
(diabetes)Tj
3.3618 0 Td
(mel-)Tj
-35.6822 -1.2982 Td
(litus[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
3.1917 0 Td
(Previous)Tj
3.5943 0 Td
(studies)Tj
2.9027 0 Td
(showed)Tj
3.1805 0 Td
(positive)Tj
3.2201 0 Td
(associations)Tj
4.8472 0 Td
(of)Tj
0.9865 0 Td
(HbA1c)Tj
3.0217 0 Td
(levels)Tj
2.3017 0 Td
(with)Tj
1.9502 0 Td
(cardiovascular)Tj
5.8337 0 Td
(dis-)Tj
-35.0303 -1.2983 Td
(ease)Tj
1.8141 0 Td
(and)Tj
1.6951 0 Td
(mortality)Tj
3.8041 0 Td
(in)Tj
1.0148 0 Td
(those)Tj
2.279 0 Td
(with)Tj
1.9446 0 Td
(diabetes)Tj
3.3675 0 Td
(mellitus[)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
5.6183 0 Td
(Microvascular)Tj
5.7769 0 Td
(complications,)Tj
5.896 0 Td
(such)Tj
2.0126 0 Td
(as)Tj
-35.223 -1.3039 Td
(nephropathy)Tj
5.2157 0 Td
(and)Tj
1.6951 0 Td
(retinopathy,)Tj
4.9492 0 Td
(are)Tj
1.4117 0 Td
(also)Tj
1.7178 0 Td
(associated)Tj
4.1385 0 Td
(with)Tj
1.9502 0 Td
(HbA1c[)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
4.3484 0 Td
(Studies)Tj
3.016 0 Td
(also)Tj
1.7235 0 Td
(observed)Tj
3.6963 0 Td
(a)Tj
0.6463 0 Td
(rela-)Tj
-34.5087 -1.2983 Td
(tionship)Tj
3.4185 0 Td
(between)Tj
3.4412 0 Td
(HbA1c)Tj
3.0218 0 Td
(and)Tj
1.6894 0 Td
(atherosclerosis)Tj
5.9244 0 Td
(among)Tj
2.9366 0 Td
(people)Tj
2.7837 0 Td
(with)Tj
1.9502 0 Td
(and)Tj
1.6894 0 Td
(without)Tj
3.2485 0 Td
(diabetes[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
-30.1037 -1.2982 Td
(Carotid)Tj
3.2031 0 Td
(intima-media)Tj
5.5332 0 Td
(thickness)Tj
3.8211 0 Td
(\(IMT\))Tj
2.6815 0 Td
(is)Tj
0.8277 0 Td
(known)Tj
2.9424 0 Td
(as)Tj
0.9921 0 Td
(a)Tj
0.6406 0 Td
(highly)Tj
2.6362 0 Td
(reproducible)Tj
5.1874 0 Td
(and)Tj
1.6951 0 Td
(non-invasive)Tj
-30.1604 -1.304 Td
(method)Tj
3.2484 0 Td
(to)Tj
1.0035 0 Td
(access)Tj
2.5738 0 Td
(atherosclerotic)Tj
5.9187 0 Td
(process[)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
6.3326 0 Td
(Increased)Tj
3.9628 0 Td
(carotid)Tj
2.965 0 Td
(IMT)Tj
2.0239 0 Td
(is)Tj
0.8221 0 Td
(also)Tj
1.7178 0 Td
(a)Tj
0.6406 0 Td
(predictor)Tj
3.8211 0 Td
(of)Tj
0.9921 0 Td
(ath-)Tj
-36.0224 -1.2982 Td
(erosclerotic)Tj
4.6998 0 Td
(cardiovascular)Tj
5.8336 0 Td
(disease)Tj
2.931 0 Td
(such)Tj
2.0126 0 Td
(as)Tj
0.9921 0 Td
(stroke)Tj
2.6079 0 Td
(and)Tj
1.6951 0 Td
(myocardial)Tj
4.5808 0 Td
(infarction[)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
7.285 0 Td
(Previous)Tj
-32.6379 -1.2983 Td
(intervention)Tj
5.0342 0 Td
(studies)Tj
2.897 0 Td
(reported)Tj
3.566 0 Td
(that)Tj
1.7291 0 Td
(there)Tj
2.2054 0 Td
(were)Tj
2.0749 0 Td
(reductions)Tj
4.354 0 Td
(of)Tj
0.9921 0 Td
(carotid)Tj
2.965 0 Td
(IMT)Tj
2.0296 0 Td
(in)Tj
1.0092 0 Td
(patients)Tj
3.2768 0 Td
(with)Tj
1.9445 0 Td
(lipid-)Tj
-34.0778 -1.2983 Td
(lowering)Tj
3.6339 0 Td
(drugs)Tj
2.4151 0 Td
(compared)Tj
4.1499 0 Td
(with)Tj
1.9446 0 Td
(a)Tj
0.6463 0 Td
(placebo)Tj
3.1918 0 Td
(group[)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
5.4878 0 Td
(In)Tj
1.0828 0 Td
(people)Tj
2.7837 0 Td
(with)Tj
1.9502 0 Td
(diagnosed)Tj
4.1725 0 Td
(and)Tj
1.6952 0 Td
(unrecog-)Tj
-33.1538 -1.3039 Td
(nized)Tj
2.3414 0 Td
(diabetes,)Tj
3.5773 0 Td
(HbA1c)Tj
3.016 0 Td
(was)Tj
1.6668 0 Td
(independently)Tj
5.8166 0 Td
(related)Tj
2.863 0 Td
(to)Tj
0.9978 0 Td
(carotid)Tj
2.965 0 Td
(IMT[)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
3.3619 0 Td
(Interestingly,)Tj
5.3234 0 Td
(HbA1c)Tj
3.0217 0 Td
(levels)Tj
-34.9509 -1.2982 Td
(were)Tj
2.0692 0 Td
(positively)Tj
3.8948 0 Td
(associated)Tj
4.1386 0 Td
(with)Tj
1.9445 0 Td
(carotid)Tj
2.965 0 Td
(IMT)Tj
2.024 0 Td
(in)Tj
1.0091 0 Td
(the)Tj
1.4286 0 Td
(people)Tj
2.7836 0 Td
(with)Tj
1.9446 0 Td
(normoglycemia)Tj
6.3496 0 Td
(as)Tj
0.9921 0 Td
(well[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
3.7757 0 Td
(How-)Tj
-35.3194 -1.2983 Td
(ever,)Tj
2.0579 0 Td
(the)Tj
1.4343 0 Td
(association)Tj
4.4957 0 Td
(was)Tj
1.6611 0 Td
(not)Tj
1.5364 0 Td
(clear)Tj
2.0636 0 Td
(in)Tj
1.0091 0 Td
(the)Tj
1.4343 0 Td
(Asian)Tj
2.4548 0 Td
(population[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
6.48 0 Td
(In)Tj
1.0828 0 Td
(an)Tj
1.1792 0 Td
(elderly)Tj
2.829 0 Td
(Asian)Tj
2.4548 0 Td
(population)Tj
-32.173 -1.3039 Td
(with)Tj
1.9445 0 Td
(normal)Tj
3.0671 0 Td
(fasting)Tj
2.7949 0 Td
(glucose)Tj
3.0841 0 Td
(levels,)Tj
2.5115 0 Td
(the)Tj
1.4286 0 Td
(association)Tj
4.4901 0 Td
(between)Tj
3.4355 0 Td
(HbA1c)Tj
3.0161 0 Td
(and)Tj
1.6894 0 Td
(subclinical)Tj
4.3313 0 Td
(carotid)Tj
2.9594 0 Td
(athero-)Tj
-34.7525 -1.2983 Td
(sclerosis)Tj
3.4298 0 Td
(has)Tj
1.5081 0 Td
(not)Tj
1.5363 0 Td
(been)Tj
2.075 0 Td
(fully)Tj
1.9275 0 Td
(investigated.)Tj
5.057 0 Td
(Thus,)Tj
2.4094 0 Td
(in)Tj
1.0148 0 Td
(the)Tj
1.4344 0 Td
(current)Tj
3.101 0 Td
(study,)Tj
2.5399 0 Td
(we)Tj
1.3039 0 Td
(evaluated)Tj
3.8834 0 Td
(the)Tj
1.4344 0 Td
(association)Tj
-32.6549 -1.2982 Td
(between)Tj
3.4412 0 Td
(HbA1c)Tj
3.0217 0 Td
(and)Tj
1.6951 0 Td
(carotid)Tj
2.965 0 Td
(IMT)Tj
2.024 0 Td
(in)Tj
1.0148 0 Td
(an)Tj
1.1792 0 Td
(elderly)Tj
2.8289 0 Td
(Korean)Tj
3.1068 0 Td
(population)Tj
4.4673 0 Td
(with)Tj
1.9503 0 Td
(normal)Tj
3.0727 0 Td
(fasting)Tj
2.8006 0 Td
(glucose.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 453.7133 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.4976 Td
(Study)Tj
2.7543 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 418.7338 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(study)Tj
2.3924 0 Td
(analyzed)Tj
3.702 0 Td
(baseline)Tj
3.4299 0 Td
(data)Tj
1.9106 0 Td
(in)Tj
1.0375 0 Td
(2012)Tj
2.1259 0 Td
(and)Tj
1.7291 0 Td
(2013)Tj
2.1203 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(Korean)Tj
3.1805 0 Td
(Urban)Tj
2.8176 0 Td
(Rural)Tj
2.4208 0 Td
(Elderly)Tj
-32.5245 -1.3039 Td
(\(KURE\))Tj
3.4979 0 Td
(study)Tj
2.3924 0 Td
(which)Tj
2.6475 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(community-based)Tj
7.4891 0 Td
(cohort)Tj
2.8573 0 Td
(study.)Tj
2.6135 0 Td
(The)Tj
1.7858 0 Td
(procedures)Tj
4.6715 0 Td
(of)Tj
1.0148 0 Td
(data)Tj
1.9162 0 Td
(collection)Tj
4.1102 0 Td
(in)Tj
-36.4986 -1.2982 Td
(KURE)Tj
2.8176 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(described)Tj
4.0535 0 Td
(elsewhere)Tj
4.1045 0 Td
(in)Tj
1.0375 0 Td
(detail)Tj
2.4151 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
3.2542 0 Td
(During)Tj
3.1351 0 Td
(the)Tj
1.4683 0 Td
(summers)Tj
3.9061 0 Td
(\(June)Tj
2.3868 0 Td
(to)Tj
1.0261 0 Td
(Septem-)Tj
-33.7887 -1.2983 Td
(ber\))Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(2012)Tj
2.1259 0 Td
(and)Tj
1.7292 0 Td
(2013,)Tj
2.347 0 Td
(a)Tj
0.652 0 Td
(total)Tj
2.0069 0 Td
(of)Tj
1.0148 0 Td
(2,025)Tj
2.3471 0 Td
(participants)Tj
4.9549 0 Td
(aged)Tj
2.075 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0239 0 Td
(65)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(were)Tj
2.1259 0 Td
(enrolled)Tj
3.515 0 Td
(from)Tj
-35.5689 -1.2983 Td
(urban)Tj
2.6078 0 Td
(and)Tj
1.7291 0 Td
(rural)Tj
2.1714 0 Td
(communities.)Tj
5.7089 0 Td
(All)Tj
1.3946 0 Td
(participants)Tj
4.9606 0 Td
(conducted)Tj
4.4277 0 Td
(questionnaire)Tj
5.7033 0 Td
(interview)Tj
3.9571 0 Td
(and)Tj
1.7292 0 Td
(health)Tj
-34.3897 -1.3039 Td
(examination)Tj
5.2327 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(prescribed)Tj
4.4164 0 Td
(protocol.)Tj
3.8211 0 Td
(Among)Tj
3.2428 0 Td
(the)Tj
1.4683 0 Td
(2,025)Tj
2.3528 0 Td
(participants,)Tj
5.1817 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(results)Tj
2.8119 0 Td
(of)Tj
-35.4101 -1.2982 Td
(physical)Tj
3.4525 0 Td
(examination,)Tj
5.4539 0 Td
(people)Tj
2.8573 0 Td
(who)Tj
1.9388 0 Td
(had)Tj
1.7065 0 Td
(a)Tj
0.6576 0 Td
(fasting)Tj
2.88 0 Td
(glucose)Tj
3.1748 0 Td
(level)Tj
/F12 1 Tf
0 Tc
2.0126 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
0.9921 0 Td
(100)Tj
1.6497 0 Td
(mg/dL)Tj
2.897 0 Td
(\(5.6)Tj
1.7405 0 Td
(mmol/L\))Tj
3.8154 0 Td
(and)Tj
-35.2287 -1.2983 Td
(an)Tj
1.1962 0 Td
(HbA1c)Tj
3.0727 0 Td
(level)Tj
/F12 1 Tf
0 Tc
2.0069 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
0.9865 0 Td
(6.5%)Tj
2.1486 0 Td
(\(48)Tj
1.5024 0 Td
(mmol/mol\))Tj
4.8528 0 Td
(were)Tj
2.1147 0 Td
(included)Tj
3.7077 0 Td
(in)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(current)Tj
3.1748 0 Td
(analysis.)Tj
3.549 0 Td
(Those)Tj
2.6419 0 Td
(with)Tj
1.9899 0 Td
(a)Tj
0.6519 0 Td
(his-)Tj
-36.0904 -1.3039 Td
(tory)Tj
1.8481 0 Td
(of)Tj
1.0148 0 Td
(major)Tj
2.6079 0 Td
(cardiovascular)Tj
6.0037 0 Td
(disease)Tj
3.0217 0 Td
(such)Tj
2.058 0 Td
(as)Tj
1.0148 0 Td
(myocardial)Tj
4.7055 0 Td
(infarction)Tj
4.1725 0 Td
(or)Tj
1.0999 0 Td
(stroke)Tj
2.6759 0 Td
(\(n)Tj
1.1111 0 Td
(=)Tj
0.7994 0 Td
(273\))Tj
1.9842 0 Td
(or)Tj
1.0999 0 Td
(who)Tj
-35.2174 -1.2983 Td
(were)Tj
2.1203 0 Td
(under)Tj
2.6191 0 Td
(treatment)Tj
4.1386 0 Td
(for)Tj
1.3833 0 Td
(diabetes)Tj
3.4639 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7994 0 Td
(349\))Tj
1.9899 0 Td
(were)Tj
2.1203 0 Td
(excluded)Tj
3.7871 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(current)Tj
3.1862 0 Td
(analysis.)Tj
3.5489 0 Td
(People)Tj
-33.9361 -1.2983 Td
(who)Tj
1.9388 0 Td
(had)Tj
1.7065 0 Td
(missing)Tj
3.3108 0 Td
(important)Tj
4.2803 0 Td
(covariate)Tj
3.8324 0 Td
(data)Tj
1.9162 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(5\))Tj
1.0318 0 Td
(were)Tj
2.126 0 Td
(also)Tj
1.7688 0 Td
(excluded.)Tj
4.0081 0 Td
(Finally,)Tj
3.1691 0 Td
(a)Tj
0.6577 0 Td
(total)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(1,133)Tj
-34.6731 -1.3039 Td
(participants)Tj
4.9549 0 Td
(were)Tj
2.126 0 Td
(included)Tj
3.7076 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(current)Tj
3.1861 0 Td
(analysis.)Tj
3.5546 0 Td
(All)Tj
1.3946 0 Td
(participants)Tj
4.955 0 Td
(provided)Tj
3.821 0 Td
(written)Tj
3.1068 0 Td
(informed)Tj
-33.3125 -1.2982 Td
(consent)Tj
3.3278 0 Td
(forms)Tj
2.5682 0 Td
(and)Tj
1.7291 0 Td
(study)Tj
2.3924 0 Td
(protocol)Tj
3.5943 0 Td
(was)Tj
1.7008 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(Institutional)Tj
5.1647 0 Td
(Review)Tj
3.0954 0 Td
(Board)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(Sever-)Tj
-33.8454 -1.2983 Td
(ance)Tj
2.0466 0 Td
(Hospital)Tj
3.6226 0 Td
(at)Tj
0.9524 0 Td
(Yonsei)Tj
2.9537 0 Td
(University)Tj
4.405 0 Td
(College)Tj
3.1975 0 Td
(of)Tj
1.0148 0 Td
(Medicine)Tj
3.9911 0 Td
(\(approval)Tj
4.0422 0 Td
(number:)Tj
3.6454 0 Td
(4-2012-0172;)Tj
-29.8713 -1.3039 Td
(approval)Tj
3.702 0 Td
(date:)Tj
2.1259 0 Td
(May)Tj
2.0013 0 Td
(3,)Tj
0.9241 0 Td
(2012\).)Tj
2.6872 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(beginning)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 209.3669 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Questionnaire)Tj
6.3685 0 Td
(data)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 192.359 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(KURE)Tj
2.8233 0 Td
(study)Tj
2.3867 0 Td
(collected)Tj
3.7418 0 Td
(information)Tj
5.0739 0 Td
(on)Tj
1.2756 0 Td
(demographics,)Tj
6.0945 0 Td
(medical)Tj
3.3618 0 Td
(history,)Tj
3.2315 0 Td
(and)Tj
1.7291 0 Td
(lifestyle)Tj
3.2258 0 Td
(using)Tj
-34.7241 -1.2982 Td
(standardized)Tj
5.3517 0 Td
(questionnaires.)Tj
6.2929 0 Td
(All)Tj
1.3946 0 Td
(interviewers)Tj
5.1137 0 Td
(were)Tj
2.126 0 Td
(trained)Tj
3.0897 0 Td
(and)Tj
1.7291 0 Td
(performed)Tj
4.4674 0 Td
(the)Tj
1.474 0 Td
(questionnaire)Tj
-31.0391 -1.3039 Td
(surveys)Tj
3.1747 0 Td
(according)Tj
4.1839 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(prescribed)Tj
4.4164 0 Td
(procedure.)Tj
4.5354 0 Td
(Smoking)Tj
3.804 0 Td
(status)Tj
2.5002 0 Td
(of)Tj
1.0148 0 Td
(participants)Tj
4.9549 0 Td
(was)Tj
1.7008 0 Td
(categorized)Tj
-32.7796 -1.2983 Td
(as)Tj
1.0147 0 Td
(current)Tj
3.1805 0 Td
(smokers)Tj
3.5603 0 Td
(or)Tj
1.0998 0 Td
(current)Tj
3.1861 0 Td
(nonsmokers.)Tj
5.3858 0 Td
(Alcohol)Tj
3.3619 0 Td
(intake)Tj
2.6929 0 Td
(was)Tj
1.6951 0 Td
(classified)Tj
3.8211 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(current)Tj
3.1805 0 Td
(study)Tj
-34.6845 -1.2983 Td
(as)Tj
1.0147 0 Td
(regular)Tj
3.0558 0 Td
(alcohol)Tj
3.1124 0 Td
(consumption)Tj
5.5445 0 Td
(\(once)Tj
2.4662 0 Td
(a)Tj
0.6519 0 Td
(week)Tj
2.2507 0 Td
(or)Tj
1.0942 0 Td
(more\))Tj
2.6815 0 Td
(or)Tj
1.0999 0 Td
(other)Tj
2.347 0 Td
(\(less)Tj
1.9503 0 Td
(than)Tj
2.0296 0 Td
(once)Tj
2.1259 0 Td
(a)Tj
0.652 0 Td
(week\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Physical)Tj
3.8976 0 Td
(examination)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(methods)Tj
3.685 0 Td
(for)Tj
1.389 0 Td
(physical)Tj
3.4469 0 Td
(examination)Tj
5.2327 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(KURE)Tj
2.8233 0 Td
(were)Tj
2.1203 0 Td
(previously)Tj
4.354 0 Td
(reported)Tj
3.6567 0 Td
(in)Tj
1.0374 0 Td
(detail)Tj
2.4151 0 Td
(else-)Tj
-34.4463 -1.2982 Td
(where[)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
6.8597 0 Td
(All)Tj
1.3947 0 Td
(participants)Tj
4.9606 0 Td
(wore)Tj
2.2053 0 Td
(identical)Tj
3.6567 0 Td
(hospital)Tj
3.3789 0 Td
(gown)Tj
2.4207 0 Td
(for)Tj
1.389 0 Td
(physical)Tj
3.4526 0 Td
(examination.)Tj
5.4538 0 Td
(A)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 394.696 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HbA1c)Tj
3.1748 0 Td
(and)Tj
1.8567 0 Td
(carotid)Tj
3.1606 0 Td
(atheroscle)Tj
4.5284 0 Td
(rosis)Tj
2.2961 0 Td
(in)Tj
0.978 0 Td
(normog)Tj
3.3307 0 Td
(lycemia)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0171)Tj
3.5434 0 Td
(761)Tj
2.6362 0 Td
(February)Tj
4.1599 0 Td
(8,)Tj
1.0417 0 Td
(2017)Tj
37.8995 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.7764 -1.3748 Td
(manuscript.)Tj
/F9 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
3.3874 0 Td
(exist.)Tj
/F9 1 Tf
-10.3394 -2.126 Td
(Abbreviati)Tj
3.9118 0 Td
(ons:)Tj
/F10 1 Tf
1.8425 0 Td
(BMI,)Tj
1.9843 0 Td
(body)Tj
2.0622 0 Td
(mass)Tj
2.2323 0 Td
(index;)Tj
2.4307 0 Td
(CRP,)Tj
2.0835 0 Td
(C-)Tj
-16.5473 -1.3748 Td
(reactive)Tj
3.0827 0 Td
(protein;)Tj
3.0401 0 Td
(DBP,)Tj
2.0835 0 Td
(diastolic)Tj
3.267 0 Td
(blood)Tj
2.3031 0 Td
(pressure;)Tj
-13.7764 -1.3748 Td
(HOMA-IR,)Tj
4.0464 0 Td
(homeostasis)Tj
4.9536 0 Td
(model)Tj
2.537 0 Td
(assess)Tj
2.5229 0 Td
(ment)Tj
2.126 0 Td
(of)Tj
-16.1859 -1.3748 Td
(insulin)Tj
2.6433 0 Td
(resistanc)Tj
3.3307 0 Td
(e;)Tj
0.8717 0 Td
(HDL,)Tj
2.0905 0 Td
(high-density)Tj
4.7977 0 Td
(lipoprotein;)Tj
-13.7339 -1.3748 Td
(IMT,)Tj
1.9275 0 Td
(intima-me)Tj
3.7701 0 Td
(dia)Tj
1.3111 0 Td
(thickness;)Tj
3.9472 0 Td
(KURE,)Tj
2.615 0 Td
(Korean)Tj
2.8418 0 Td
(Urban)Tj
-16.4127 -1.3748 Td
(Rural)Tj
2.2039 0 Td
(Elderly;)Tj
2.9268 0 Td
(LDL,)Tj
1.9772 0 Td
(Low-density)Tj
4.7764 0 Td
(lipoprote)Tj
3.2599 0 Td
(in;)Tj
1.1126 0 Td
(SBP,)Tj
-16.2568 -1.3748 Td
(Systolic)Tj
3.1252 0 Td
(blood)Tj
ET
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
BT
5.4283 68.8399 Td
(pressure.)Tj
ET
Q
endstream
endobj
60 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 63 0 R/Contents 64 0 R/TrimBox[0 0 612 792]>>
endobj
61 0 obj
<>
endobj
65 0 obj
<>
endobj
66 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Symbols def
/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 128 /ff put
dup 129 /ffi put
dup 130 /ffl put
dup 131 /C131 put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 138 /C138 put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤(HwK7X7
Mr:E%]3<Ӝ$wrAQ4ADt%̏>E hAجm*pu@>#6aZi}NRmƼ%
,OgX' EX?ڞ\#JEG<IXS}Eh[ş8ї48ٶ.w4bJ?_nfulqD?둓\C%+' { L9K7isW+ӕ(6oɧVҺlS;5K
Z%.oQՕW*9Qk_S+B-}%lYC@WP0b\KKdi>t,n_S[ '9`-z+cڦEb#c@;yɸoAT O_H~i -6ϰ豟Ae&BF+
wNX!=hhUF8(hZ6pgJc m'9dx*^wXc
գ<.쯶c ln)/LvXY2jbF:ȸ3'>\Ȥmzj,!:ZK' (q/ -&&S ؤ-bm KQSxLGu `D3yԱKaVMU§ %iq5%s 2SdR#ho45H.4TdՊa<K>BqG- Ao, (e&F2gG`z8*༠&
x#B
B;8!93~T/ \>nLazCSKm~,!_<ӾX@X@N2vEt בFmBYa wRG[i;+oM+%(8 jԀlIW>t