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Perfusion Parameters on Breast Dynamic Contrast-Enhanced MRI Are Associated With Disease-Specific Survival in Patients With Triple-Negative Breast Cancer

Authors
 Vivian Youngjean Park  ;  Eun-Kyung Kim  ;  Min Jung Kim  ;  Jung Hyun Yoon  ;  Hee Jung Moon 
Citation
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.208(3) : 687-694, 2017 
Journal Title
 AMERICAN JOURNAL OF ROENTGENOLOGY 
ISSN
 0361-803X 
Issue Date
2017
MeSH
Adult ; Aged ; Breast/blood supply ; Breast/diagnostic imaging* ; Contrast Media ; Disease-Free Survival ; Female ; Humans ; Incidence ; Magnetic Resonance Angiography/methods ; Magnetic Resonance Angiography/statistics & numerical data* ; Middle Aged ; Neovascularization, Pathologic/diagnostic imaging* ; Neovascularization, Pathologic/mortality* ; Prognosis ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment/methods ; Survival Rate ; Triple Negative Breast Neoplasms/diagnostic imaging* ; Triple Negative Breast Neoplasms/mortality*
Keywords
MRI ; survival outcome ; triple-negative breast cancer (TNBC)
Abstract
OBJECTIVE: The aim of this study was to investigate the association between perfusion parameters on MRI performed before treatment and survival outcome (disease-free survival [DFS], disease-specific survival [DSS]) in patients with triple-negative breast cancer (TNBC). MATERIALS AND METHODS: Sixty-one patients (median age, 50 years; age range, 27-77 years) with TNBC (tumor size on MRI: median, 25.5 mm; range, 11.0-142.0 mm) were included. We analyzed clinical and pathologic variables and MRI parameters. Cox proportional hazards models were used to determine associations with survival outcome. RESULTS: The median follow-up time was 46.1 months (range, 13.9-58.4 months). Eleven of 61 (18.0%) patients had events (i.e., local, regional, or distant recurrence or contralateral breast cancer) and seven (11.5%) died of breast cancer. Among the pretreatment variables, a larger tumor size on MR images (hazard ratio [HR] = 1.024, p = 0.003) was associated with worse DFS at univariate analysis. In multivariate pretreatment models for DSS, a higher fractional volume of extravascular extracellular space per unit volume of tissue (ve) value (HR = 1.658, p = 0.038), higher peak enhancement (HR = 1.843, p = 0.018), and a larger tumor size on MR images (HR = 1.060, p = 0.001) were associated with worse DSS. In multivariate posttreatment models, a larger pathologic tumor size (HR for DFS, 1.074 [p = 0.005]; HR for DSS, 1.050 [p = 0.042]) and metastasis in surgically resected axillary lymph nodes (HR for DFS, 5.789 [p = 0.017]; HR for DSS, 23.717 [p = 0.005]) were associated with worse survival outcome. CONCLUSION: A higher ve value, higher peak enhancement, and larger tumor size of the primary tumor on pretreatment MRI were independent predictors of worse DSS in patients with TNBC.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.16.16476
DOI
10.2214/AJR.16.16476
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154627
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