0 167

Cited 3 times in

Perfusion Parameters on Breast Dynamic Contrast-Enhanced MRI Are Associated With Disease-Specific Survival in Patients With Triple-Negative Breast Cancer

 Vivian Youngjean Park  ;  Eun-Kyung Kim  ;  Min Jung Kim  ;  Jung Hyun Yoon  ;  Hee Jung Moon 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.208(3) : 687-694, 2017 
Journal Title
Issue Date
Adult ; Aged ; Breast/blood supply ; Breast/diagnostic imaging* ; Contrast Media ; Disease-Free Survival ; Female ; Humans ; Incidence ; Magnetic Resonance Angiography/methods ; Magnetic Resonance Angiography/statistics & numerical data* ; Middle Aged ; Neovascularization, Pathologic/diagnostic imaging* ; Neovascularization, Pathologic/mortality* ; Prognosis ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment/methods ; Survival Rate ; Triple Negative Breast Neoplasms/diagnostic imaging* ; Triple Negative Breast Neoplasms/mortality*
MRI ; survival outcome ; triple-negative breast cancer (TNBC)
OBJECTIVE: The aim of this study was to investigate the association between perfusion parameters on MRI performed before treatment and survival outcome (disease-free survival [DFS], disease-specific survival [DSS]) in patients with triple-negative breast cancer (TNBC). MATERIALS AND METHODS: Sixty-one patients (median age, 50 years; age range, 27-77 years) with TNBC (tumor size on MRI: median, 25.5 mm; range, 11.0-142.0 mm) were included. We analyzed clinical and pathologic variables and MRI parameters. Cox proportional hazards models were used to determine associations with survival outcome. RESULTS: The median follow-up time was 46.1 months (range, 13.9-58.4 months). Eleven of 61 (18.0%) patients had events (i.e., local, regional, or distant recurrence or contralateral breast cancer) and seven (11.5%) died of breast cancer. Among the pretreatment variables, a larger tumor size on MR images (hazard ratio [HR] = 1.024, p = 0.003) was associated with worse DFS at univariate analysis. In multivariate pretreatment models for DSS, a higher fractional volume of extravascular extracellular space per unit volume of tissue (ve) value (HR = 1.658, p = 0.038), higher peak enhancement (HR = 1.843, p = 0.018), and a larger tumor size on MR images (HR = 1.060, p = 0.001) were associated with worse DSS. In multivariate posttreatment models, a larger pathologic tumor size (HR for DFS, 1.074 [p = 0.005]; HR for DSS, 1.050 [p = 0.042]) and metastasis in surgically resected axillary lymph nodes (HR for DFS, 5.789 [p = 0.017]; HR for DSS, 23.717 [p = 0.005]) were associated with worse survival outcome. CONCLUSION: A higher ve value, higher peak enhancement, and larger tumor size of the primary tumor on pretreatment MRI were independent predictors of worse DSS in patients with TNBC.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.