Cited 12 times in
Perfusion Parameters on Breast Dynamic Contrast-Enhanced MRI Are Associated With Disease-Specific Survival in Patients With Triple-Negative Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.contributor.author | 박영진 | - |
dc.contributor.author | 윤정현 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.date.accessioned | 2017-11-02T08:34:26Z | - |
dc.date.available | 2017-11-02T08:34:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0361-803X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154627 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to investigate the association between perfusion parameters on MRI performed before treatment and survival outcome (disease-free survival [DFS], disease-specific survival [DSS]) in patients with triple-negative breast cancer (TNBC). MATERIALS AND METHODS: Sixty-one patients (median age, 50 years; age range, 27-77 years) with TNBC (tumor size on MRI: median, 25.5 mm; range, 11.0-142.0 mm) were included. We analyzed clinical and pathologic variables and MRI parameters. Cox proportional hazards models were used to determine associations with survival outcome. RESULTS: The median follow-up time was 46.1 months (range, 13.9-58.4 months). Eleven of 61 (18.0%) patients had events (i.e., local, regional, or distant recurrence or contralateral breast cancer) and seven (11.5%) died of breast cancer. Among the pretreatment variables, a larger tumor size on MR images (hazard ratio [HR] = 1.024, p = 0.003) was associated with worse DFS at univariate analysis. In multivariate pretreatment models for DSS, a higher fractional volume of extravascular extracellular space per unit volume of tissue (ve) value (HR = 1.658, p = 0.038), higher peak enhancement (HR = 1.843, p = 0.018), and a larger tumor size on MR images (HR = 1.060, p = 0.001) were associated with worse DSS. In multivariate posttreatment models, a larger pathologic tumor size (HR for DFS, 1.074 [p = 0.005]; HR for DSS, 1.050 [p = 0.042]) and metastasis in surgically resected axillary lymph nodes (HR for DFS, 5.789 [p = 0.017]; HR for DSS, 23.717 [p = 0.005]) were associated with worse survival outcome. CONCLUSION: A higher ve value, higher peak enhancement, and larger tumor size of the primary tumor on pretreatment MRI were independent predictors of worse DSS in patients with TNBC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Springfield, Ill., Thomas | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF ROENTGENOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Breast/blood supply | - |
dc.subject.MESH | Breast/diagnostic imaging* | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Magnetic Resonance Angiography/methods | - |
dc.subject.MESH | Magnetic Resonance Angiography/statistics & numerical data* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neovascularization, Pathologic/diagnostic imaging* | - |
dc.subject.MESH | Neovascularization, Pathologic/mortality* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment/methods | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/mortality* | - |
dc.title | Perfusion Parameters on Breast Dynamic Contrast-Enhanced MRI Are Associated With Disease-Specific Survival in Patients With Triple-Negative Breast Cancer | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Vivian Youngjean Park | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.identifier.doi | 10.2214/AJR.16.16476 | - |
dc.contributor.localId | A01572 | - |
dc.contributor.localId | A02595 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A00473 | - |
dc.relation.journalcode | J00116 | - |
dc.identifier.eissn | 1546-3141 | - |
dc.identifier.pmid | 28004976 | - |
dc.identifier.url | http://www.ajronline.org/doi/abs/10.2214/AJR.16.16476 | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | survival outcome | - |
dc.subject.keyword | triple-negative breast cancer (TNBC) | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.alternativeName | Park, Vivian Young Jean | - |
dc.contributor.alternativeName | Yoon, Jung Hyun | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Park, Vivian Youngjean | - |
dc.contributor.affiliatedAuthor | Yoon, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Min Jung | - |
dc.citation.title | American Journal of Roentgenology | - |
dc.citation.volume | 208 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 687 | - |
dc.citation.endPage | 694 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.208(3) : 687-694, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43685 | - |
dc.type.rims | ART | - |
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