80 132

Cited 2 times in

Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures

Authors
 Jae Won Shin  ;  Yun Seob Jung  ;  Kyungsoo Park  ;  Soon Min Lee  ;  Ho Seon Eun  ;  Min Soo Park  ;  Kook In Park  ;  Ran Namgung 
Citation
 Korean Journal of Pediatrics, Vol.60(2) : 50-54, 2017 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2017
Keywords
Levetiracetam ; Neonatal seizure ; Pharmacokinetics ; Population pharmacokinetics ; Safety
Abstract
PURPOSE: The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. METHODS: A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day. RESULTS: Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults. CONCLUSION: LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring.
Files in This Item:
T201701566.pdf Download
DOI
10.3345/kjp.2017.60.2.50
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
남궁란(Namgung, Ran) ORCID logo https://orcid.org/0000-0001-7182-9535
박경수(Park, Kyungsoo) ORCID logo https://orcid.org/0000-0002-6972-1143
박국인(Park, Kook In) ORCID logo https://orcid.org/0000-0001-8499-9293
박민수(Park, Min Soo) ORCID logo https://orcid.org/0000-0002-4395-9938
신재원(Shin, Jae Won)
은호선(Eun, Ho Seon) ORCID logo https://orcid.org/0000-0001-7212-0341
이순민(Lee, Soon Min) ORCID logo https://orcid.org/0000-0003-0174-1065
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154387
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse