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Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures

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dc.contributor.author남궁란-
dc.contributor.author박경수-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author신재원-
dc.contributor.author은호선-
dc.contributor.author이순민-
dc.date.accessioned2017-11-02T08:22:12Z-
dc.date.available2017-11-02T08:22:12Z-
dc.date.issued2017-
dc.identifier.issn1738-1061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154387-
dc.description.abstractPURPOSE: The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. METHODS: A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day. RESULTS: Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults. CONCLUSION: LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한소아과학회-
dc.relation.isPartOfKorean Journal of Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExperience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorJae Won Shin-
dc.contributor.googleauthorYun Seob Jung-
dc.contributor.googleauthorKyungsoo Park-
dc.contributor.googleauthorSoon Min Lee-
dc.contributor.googleauthorHo Seon Eun-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorKook In Park-
dc.contributor.googleauthorRan Namgung-
dc.identifier.doi10.3345/kjp.2017.60.2.50-
dc.contributor.localIdA01422-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA05144-
dc.contributor.localIdA02635-
dc.contributor.localIdA02905-
dc.contributor.localIdA01241-
dc.relation.journalcodeJ02100-
dc.identifier.eissn2092-7258-
dc.relation.journalsince2004~-
dc.identifier.pmid28289434-
dc.relation.journalbefore~2003 Korean Journal of Pediatrics-
dc.subject.keywordLevetiracetam-
dc.subject.keywordNeonatal seizure-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordPopulation pharmacokinetics-
dc.subject.keywordSafety-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kyung Soo-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameShin, Jae Won-
dc.contributor.alternativeNameEun, Ho Seon-
dc.contributor.alternativeNameLee, Soon Min-
dc.contributor.affiliatedAuthorPark, Kyung Soo-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorShin, Jae Won-
dc.contributor.affiliatedAuthorEun, Ho Seon-
dc.contributor.affiliatedAuthorLee, Soon Min-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.citation.titleKorean Journal of Pediatrics-
dc.citation.volume60-
dc.citation.number2-
dc.citation.startPage50-
dc.citation.endPage54-
dc.identifier.bibliographicCitationKorean Journal of Pediatrics, Vol.60(2) : 50-54, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42958-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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