Cited 10 times in
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남궁란 | - |
dc.contributor.author | 박경수 | - |
dc.contributor.author | 박국인 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 신재원 | - |
dc.contributor.author | 은호선 | - |
dc.contributor.author | 이순민 | - |
dc.date.accessioned | 2017-11-02T08:22:12Z | - |
dc.date.available | 2017-11-02T08:22:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154387 | - |
dc.description.abstract | PURPOSE: The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. METHODS: A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day. RESULTS: Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults. CONCLUSION: LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Jae Won Shin | - |
dc.contributor.googleauthor | Yun Seob Jung | - |
dc.contributor.googleauthor | Kyungsoo Park | - |
dc.contributor.googleauthor | Soon Min Lee | - |
dc.contributor.googleauthor | Ho Seon Eun | - |
dc.contributor.googleauthor | Min Soo Park | - |
dc.contributor.googleauthor | Kook In Park | - |
dc.contributor.googleauthor | Ran Namgung | - |
dc.identifier.doi | 10.3345/kjp.2017.60.2.50 | - |
dc.contributor.localId | A01422 | - |
dc.contributor.localId | A01438 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A05144 | - |
dc.contributor.localId | A02635 | - |
dc.contributor.localId | A02905 | - |
dc.contributor.localId | A01241 | - |
dc.relation.journalcode | J02100 | - |
dc.identifier.eissn | 2092-7258 | - |
dc.relation.journalsince | 2004~ | - |
dc.identifier.pmid | 28289434 | - |
dc.relation.journalbefore | ~2003 Korean Journal of Pediatrics | - |
dc.subject.keyword | Levetiracetam | - |
dc.subject.keyword | Neonatal seizure | - |
dc.subject.keyword | Pharmacokinetics | - |
dc.subject.keyword | Population pharmacokinetics | - |
dc.subject.keyword | Safety | - |
dc.contributor.alternativeName | Namgung, Ran | - |
dc.contributor.alternativeName | Park, Kyung Soo | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.alternativeName | Park, Min Soo | - |
dc.contributor.alternativeName | Shin, Jae Won | - |
dc.contributor.alternativeName | Eun, Ho Seon | - |
dc.contributor.alternativeName | Lee, Soon Min | - |
dc.contributor.affiliatedAuthor | Park, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Park, Min Soo | - |
dc.contributor.affiliatedAuthor | Shin, Jae Won | - |
dc.contributor.affiliatedAuthor | Eun, Ho Seon | - |
dc.contributor.affiliatedAuthor | Lee, Soon Min | - |
dc.contributor.affiliatedAuthor | Namgung, Ran | - |
dc.citation.title | Korean Journal of Pediatrics | - |
dc.citation.volume | 60 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 54 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, Vol.60(2) : 50-54, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42958 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.