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Cognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson's Disease Dementia

 Kim, Younggwang  ;  Lee, Dongkyun  ;  Cho, Kyoo Ho  ;  Lee, Jae Jung  ;  Ham, Jee Hyun  ;  Ye, Byoung Seok  ;  Lee, Seung-Koo  ;  Lee, Jong-Min  ;  Sohn, Young H  ;  Lee, Phil Hyu 
 JOURNAL OF ALZHEIMERS DISEASE, Vol.55(2) : 485-495, 2017 
Journal Title
Issue Date
Age of Onset ; Aged ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology* ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/etiology* ; Cognition Disorders/pathology ; Dementia/complications* ; Dementia/diagnostic imaging ; Female ; Fluorine Radioisotopes/metabolism ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/complications* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/pathology* ; Statistics, Nonparametric ; Tropanes/metabolism
Age at onset ; Parkinson’s disease dementia ; neuroanatomical correlates ; neurocognitive performance
BACKGROUND: Aging is the most important risk factor of development of dementia in Parkinson's disease (PD), but there are no data on clinical and radiological heterogeneity of PD dementia (PDD) depending on age at onset. OBJECTIVES: The goal of this study was to examine whether patients with PDD are clinically and radiologically heterogeneous depending on age at onset. METHODS: A total of 116 patients with PD dementia and 121 age- and sex-matched normal controls were enrolled. The subjects were divided into early-onset (EOPDD; n = 39) and late-onset (LOPDD; n = 77) PDD with the respective age-matched control group based on a cutoff value of 70 years. The effects of diagnosis, age, and their interaction on neuropsychological tests, cortical thickness, and substantia innominata volume were assessed using analysis of covariance. RESULTS: EOPDD patients had a poorer cognitive performance on digit backward, forward span test (p = 0.011 and 0.05), and visual recognition memory function (p = 0.012) compared with LOPDD patients. Additionally, EOPDD patients exhibited cortical thinning in the left anterior cingulate gyrus and the right inferior temporal gyrus, with significantly decreased normalized substantia innominata volume (p = 0.044). CONCLUSIONS: Our data demonstrated that EOPDD patients exhibit poorer cognitive performance and more severe atrophy in the cortex and substantia innominata, implying that EOPDD may be a distinct phenotype different from LOPDD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
Ham, Jee Hyun(함지현)
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