Cited 6 times in
Cognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson's Disease Dementia
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 이재정 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 조규호 | - |
dc.contributor.author | 함지현 | - |
dc.contributor.author | 김영광 | - |
dc.date.accessioned | 2017-11-02T07:51:51Z | - |
dc.date.available | 2017-11-02T07:51:51Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154058 | - |
dc.description.abstract | BACKGROUND: Aging is the most important risk factor of development of dementia in Parkinson's disease (PD), but there are no data on clinical and radiological heterogeneity of PD dementia (PDD) depending on age at onset. OBJECTIVES: The goal of this study was to examine whether patients with PDD are clinically and radiologically heterogeneous depending on age at onset. METHODS: A total of 116 patients with PD dementia and 121 age- and sex-matched normal controls were enrolled. The subjects were divided into early-onset (EOPDD; n = 39) and late-onset (LOPDD; n = 77) PDD with the respective age-matched control group based on a cutoff value of 70 years. The effects of diagnosis, age, and their interaction on neuropsychological tests, cortical thickness, and substantia innominata volume were assessed using analysis of covariance. RESULTS: EOPDD patients had a poorer cognitive performance on digit backward, forward span test (p = 0.011 and 0.05), and visual recognition memory function (p = 0.012) compared with LOPDD patients. Additionally, EOPDD patients exhibited cortical thinning in the left anterior cingulate gyrus and the right inferior temporal gyrus, with significantly decreased normalized substantia innominata volume (p = 0.044). CONCLUSIONS: Our data demonstrated that EOPDD patients exhibit poorer cognitive performance and more severe atrophy in the cortex and substantia innominata, implying that EOPDD may be a distinct phenotype different from LOPDD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age of Onset | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cerebral Cortex/diagnostic imaging | - |
dc.subject.MESH | Cerebral Cortex/pathology* | - |
dc.subject.MESH | Cognition Disorders/diagnostic imaging | - |
dc.subject.MESH | Cognition Disorders/etiology* | - |
dc.subject.MESH | Cognition Disorders/pathology | - |
dc.subject.MESH | Dementia/complications* | - |
dc.subject.MESH | Dementia/diagnostic imaging | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorine Radioisotopes/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Parkinson Disease/complications* | - |
dc.subject.MESH | Parkinson Disease/diagnostic imaging | - |
dc.subject.MESH | Parkinson Disease/pathology* | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Tropanes/metabolism | - |
dc.title | Cognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson's Disease Dementia | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Kim, Younggwang | - |
dc.contributor.googleauthor | Lee, Dongkyun | - |
dc.contributor.googleauthor | Cho, Kyoo Ho | - |
dc.contributor.googleauthor | Lee, Jae Jung | - |
dc.contributor.googleauthor | Ham, Jee Hyun | - |
dc.contributor.googleauthor | Ye, Byoung Seok | - |
dc.contributor.googleauthor | Lee, Seung-Koo | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Sohn, Young H | - |
dc.contributor.googleauthor | Lee, Phil Hyu | - |
dc.identifier.doi | 10.3233/JAD-160597 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03082 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A03811 | - |
dc.contributor.localId | A04338 | - |
dc.contributor.localId | A01982 | - |
dc.relation.journalcode | J01231 | - |
dc.identifier.eissn | 1875-8908 | - |
dc.identifier.pmid | 27662310 | - |
dc.identifier.url | http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160597 | - |
dc.subject.keyword | Age at onset | - |
dc.subject.keyword | Parkinson’s disease dementia | - |
dc.subject.keyword | neuroanatomical correlates | - |
dc.subject.keyword | neurocognitive performance | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Ye, Byoung Seok | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Lee, Jae Jung | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.alternativeName | Cho, Kyoo Ho | - |
dc.contributor.alternativeName | Ham, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Ye, Byoung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Lee, Jae Jung | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Ham, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.citation.title | Journal of Alzheimers Disease | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 485 | - |
dc.citation.endPage | 495 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, Vol.55(2) : 485-495, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 41557 | - |
dc.type.rims | ART | - |
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