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Cognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson's Disease Dementia

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author이승구-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.contributor.author조규호-
dc.contributor.author함지현-
dc.contributor.author김영광-
dc.date.accessioned2017-11-02T07:51:51Z-
dc.date.available2017-11-02T07:51:51Z-
dc.date.issued2017-
dc.identifier.issn1387-2877-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154058-
dc.description.abstractBACKGROUND: Aging is the most important risk factor of development of dementia in Parkinson's disease (PD), but there are no data on clinical and radiological heterogeneity of PD dementia (PDD) depending on age at onset. OBJECTIVES: The goal of this study was to examine whether patients with PDD are clinically and radiologically heterogeneous depending on age at onset. METHODS: A total of 116 patients with PD dementia and 121 age- and sex-matched normal controls were enrolled. The subjects were divided into early-onset (EOPDD; n = 39) and late-onset (LOPDD; n = 77) PDD with the respective age-matched control group based on a cutoff value of 70 years. The effects of diagnosis, age, and their interaction on neuropsychological tests, cortical thickness, and substantia innominata volume were assessed using analysis of covariance. RESULTS: EOPDD patients had a poorer cognitive performance on digit backward, forward span test (p = 0.011 and 0.05), and visual recognition memory function (p = 0.012) compared with LOPDD patients. Additionally, EOPDD patients exhibited cortical thinning in the left anterior cingulate gyrus and the right inferior temporal gyrus, with significantly decreased normalized substantia innominata volume (p = 0.044). CONCLUSIONS: Our data demonstrated that EOPDD patients exhibit poorer cognitive performance and more severe atrophy in the cortex and substantia innominata, implying that EOPDD may be a distinct phenotype different from LOPDD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOS Press-
dc.relation.isPartOfJOURNAL OF ALZHEIMERS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge of Onset-
dc.subject.MESHAged-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCerebral Cortex/diagnostic imaging-
dc.subject.MESHCerebral Cortex/pathology*-
dc.subject.MESHCognition Disorders/diagnostic imaging-
dc.subject.MESHCognition Disorders/etiology*-
dc.subject.MESHCognition Disorders/pathology-
dc.subject.MESHDementia/complications*-
dc.subject.MESHDementia/diagnostic imaging-
dc.subject.MESHFemale-
dc.subject.MESHFluorine Radioisotopes/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/complications*-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/pathology*-
dc.subject.MESHStatistics, Nonparametric-
dc.subject.MESHTropanes/metabolism-
dc.titleCognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson's Disease Dementia-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorKim, Younggwang-
dc.contributor.googleauthorLee, Dongkyun-
dc.contributor.googleauthorCho, Kyoo Ho-
dc.contributor.googleauthorLee, Jae Jung-
dc.contributor.googleauthorHam, Jee Hyun-
dc.contributor.googleauthorYe, Byoung Seok-
dc.contributor.googleauthorLee, Seung-Koo-
dc.contributor.googleauthorLee, Jong-Min-
dc.contributor.googleauthorSohn, Young H-
dc.contributor.googleauthorLee, Phil Hyu-
dc.identifier.doi10.3233/JAD-160597-
dc.contributor.localIdA04603-
dc.contributor.localIdA02912-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA03811-
dc.contributor.localIdA04338-
dc.contributor.localIdA01982-
dc.relation.journalcodeJ01231-
dc.identifier.eissn1875-8908-
dc.identifier.pmid27662310-
dc.identifier.urlhttp://content.iospress.com/articles/journal-of-alzheimers-disease/jad160597-
dc.subject.keywordAge at onset-
dc.subject.keywordParkinson’s disease dementia-
dc.subject.keywordneuroanatomical correlates-
dc.subject.keywordneurocognitive performance-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameYe, Byoung Seok-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameCho, Kyoo Ho-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.affiliatedAuthorYe, Byoung Seok-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorCho, Kyoo Ho-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.citation.titleJournal of Alzheimers Disease-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage485-
dc.citation.endPage495-
dc.identifier.bibliographicCitationJOURNAL OF ALZHEIMERS DISEASE, Vol.55(2) : 485-495, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid41557-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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