90 126

Cited 3 times in

Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study.

Authors
 Jee-Yon Lee  ;  Mi-Kyung Lee  ;  Nam-Kyu Kim  ;  Sang-Hui Chu  ;  Duk-Chul Lee  ;  Hye-Sun Lee  ;  Ji-Won Lee  ;  Justin Y. Jeon 
Citation
 PLoS One, Vol.12(5) : e0176929, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Chemokines/blood* ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/physiopathology* ; Female ; Humans ; Intercellular Signaling Peptides and Proteins/blood* ; Male ; Middle Aged ; Pilot Projects ; Quality of Life* ; Survivors*
Abstract
BACKGROUND: Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors. METHODS: A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors. RESULTS: Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r = -0.22, p<0.02), FACT-Colorectal cancer (C) (r = -0.23, p<0.02) and FACT-Fatigue (F) scores (r = -0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β = -0.15, p<0.01; enter: β = -0.12, p = 0.02), FACT-C (stepwise: β = -0.19, p<0.01; enter; β = -0.14, p = 0.02) and FACT-F scores (stepwise: β = -0.23, p<0.01; enter: β = -0.20, p<0.01). CONCLUSIONS: Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.
Files in This Item:
T201701298.pdf Download
DOI
10.1371/journal.pone.0176929
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
이덕철(Lee, Duk Chul) ORCID logo https://orcid.org/0000-0001-9166-1813
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153672
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse