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Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?

 Seok Woo Yang  ;  Seong-Ho Kang  ;  Kyung Rae Kim  ;  In Hong Choi  ;  Hang Seok Chang  ;  Young Lyun Oh  ;  Soon Won Hong 
 Journal of Pathology and Translational Medicine, Vol.50(5) : 377-384, 2016 
Journal Title
 Journal of Pathology and Translational Medicine 
Issue Date
Cyclin-dependent kinase inhibitor p27 ; Cytokines ; Lymphocytic thyroiditis ; Neoplasm metastasis ; T-lymphocytes, helper-inducer ; Thyroid cancer, papillary
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used. The prognostic parameters (tumor size, extra-thyroidal extension of PTC, and lymph node metastasis) were analyzed. The mRNA levels of two subtypes of Th cytokines, Th1 (tumor necrosis factor α [TNF-α], interferon γ [IFN-γ ], and interleukin [IL] 2) and Th2 (IL-4 and IL-10), were analyzed. Because most PTC cases were microcarcinomas and recent cases without clinical follow-up, negative or faint p27 immunoreactivity was used as a surrogate marker for lymph node metastasis. RESULTS: PTC with LT cases showed significantly higher expression of TNF-α (p = .043), IFN-γ (p < .010), IL-4 (p = .015) than those without LT cases. Although the data were not statistically significant, all analyzed cytokines (except for IL-4) were highly expressed in the cases with higher expression of p27 surrogate marker. CONCLUSIONS: These results indicate that mixed Th1 (TNF-α, IFN-γ , and IL-2) and Th2 (IL-10) immunity might play a role in the antitumor effect in terms of lymph node metastasis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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