Cited 2 times in
Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?
DC Field | Value | Language |
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dc.contributor.author | 김경래 | - |
dc.contributor.author | 장항석 | - |
dc.contributor.author | 최인홍 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2017-10-26T08:12:43Z | - |
dc.date.available | 2017-10-26T08:12:43Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153136 | - |
dc.description.abstract | BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used. The prognostic parameters (tumor size, extra-thyroidal extension of PTC, and lymph node metastasis) were analyzed. The mRNA levels of two subtypes of Th cytokines, Th1 (tumor necrosis factor α [TNF-α], interferon γ [IFN-γ ], and interleukin [IL] 2) and Th2 (IL-4 and IL-10), were analyzed. Because most PTC cases were microcarcinomas and recent cases without clinical follow-up, negative or faint p27 immunoreactivity was used as a surrogate marker for lymph node metastasis. RESULTS: PTC with LT cases showed significantly higher expression of TNF-α (p = .043), IFN-γ (p < .010), IL-4 (p = .015) than those without LT cases. Although the data were not statistically significant, all analyzed cytokines (except for IL-4) were highly expressed in the cases with higher expression of p27 surrogate marker. CONCLUSIONS: These results indicate that mixed Th1 (TNF-α, IFN-γ , and IL-2) and Th2 (IL-10) immunity might play a role in the antitumor effect in terms of lymph node metastasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | The Korean Society of Pathologists | - |
dc.relation.isPartOf | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect? | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Seok Woo Yang | - |
dc.contributor.googleauthor | Seong-Ho Kang | - |
dc.contributor.googleauthor | Kyung Rae Kim | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.contributor.googleauthor | Hang Seok Chang | - |
dc.contributor.googleauthor | Young Lyun Oh | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.identifier.doi | 10.4132/jptm.2016.07.25 | - |
dc.contributor.localId | A03488 | - |
dc.contributor.localId | A04167 | - |
dc.contributor.localId | A04411 | - |
dc.contributor.localId | A00294 | - |
dc.relation.journalcode | J01680 | - |
dc.identifier.eissn | 2383-7845 | - |
dc.relation.journalsince | 2015~ | - |
dc.identifier.pmid | 27681413 | - |
dc.relation.journalbefore | ~2014 Korean Journal of Pathology | - |
dc.subject.keyword | Cyclin-dependent kinase inhibitor p27 | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Lymphocytic thyroiditis | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.subject.keyword | T-lymphocytes, helper-inducer | - |
dc.subject.keyword | Thyroid cancer, papillary | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Chang, Hang Seok | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Chang, Hang Seok | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Rae | - |
dc.citation.volume | 50 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 377 | - |
dc.citation.endPage | 384 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.50(5) : 377-384, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41137 | - |
dc.type.rims | ART | - |
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