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Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction

 Re-Mee Doh  ;  Sungtae Kim  ;  Ki Chang Keum  ;  Jun Won Kim  ;  June-Sung Shim  ;  Han-Sung Jung  ;  Kyeong-Mee Park  ;  Moon-Kyu Chung 
 Journal of Advanced Prosthodontics, Vol.8(5) : 363-371, 2016 
Journal Title
 Journal of Advanced Prosthodontics 
Issue Date
PURPOSE: On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages. MATERIALS AND METHODS: Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation). RESULTS: The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study. CONCLUSION: Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Shim, June Sung(심준성) ORCID logo https://orcid.org/0000-0003-1428-0122
Chung, Moon Kyu(정문규)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
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