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Optimal Acquisition Number for Hepatic Shear Wave Velocity Measurements in Children

 Hyun Joo Shin  ;  Myung-Joon Kim  ;  Ha Yan Kim  ;  Yun Ho Roh  ;  Mi-Jung Lee 
 PLOS ONE, Vol.11(12) : e0168758, 2016 
Journal Title
Issue Date
Adolescent ; Child ; Child, Preschool ; Elasticity Imaging Techniques* ; Female ; Humans ; Infant ; Infant, Newborn ; Liver/diagnostic imaging ; Liver/physiology* ; Male ; Prospective Studies ; Respiratory Rate/physiology
OBJECTIVE: To investigate the minimum optimal acquisition number of hepatic shear wave velocities (SWVs) on ultrasound elastography in children.

MATERIALS AND METHODS: We prospectively performed hepatic supersonic shear wave elastography in children of four groups (group A-C, healthy children, group A with 0-5 years old; group B with 6-10 years old; group C with 11-18 years old; and group D, children with previous Kasai operation) with free breathing (FB) and breath holding (BH) status, if possible. SWVs were measured fifteen times for each child at a 4 cm depth for the right lobe using a 1-6 MHz convex transducer. Mean SWVs from three, five, and seven acquisitions were compared to the mean SWV from fifteen measurements, using an intraclass correlation coefficient (ICC) analyzed with the 1,000 times bootstrap method.

RESULTS: Total eighty-eight children were included (25 children in group A, 30 children in group B, 21 children in group C, and 12 children in group D). The mean SWVs from fifteen measurements in FB status were 5.5 ± 1.3 kPa for groups A-C together and 8.0 ± 2.2 kPa for group D. For all groups together, mean SWVs from the three (ICC 0.944 and 0.937), five (ICC 0.958 and 0.938) and seven (ICC 0.969 and 0.941) acquisitions demonstrated almost perfect agreement with the reference of fifteen acquisitions in both FB and BH status, respectively. A subgroup analysis showed three measurements were in almost perfect agreement during FB for groups B-D and strong agreement (ICC 0.675) for group A.

CONCLUSION: Three acquisitions can be enough for hepatic SWVs in children more than 6 years old regardless of breathing status or hepatic pathology. More acquisitions are recommended for children under the age of 5 years during FB.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Kim, Ha Yan(김하얀)
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
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