137 177

Cited 3 times in

What is the impact of child abuse on gray matter abnormalities in individuals with major depressive disorder: a case control study

 Sung Jun Ahn  ;  Sunghyon Kyeong  ;  Sang Hyun Suh  ;  Jae-Jin Kim  ;  Tae-Sub Chung  ;  Jeong-Ho Seok 
 BMC PSYCHIATRY, Vol.16(1) : 397, 2016 
Journal Title
Issue Date
Adult ; Adult Survivors of Child Abuse/psychology* ; Brain/pathology* ; Case-Control Studies ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/pathology* ; Female ; Gray Matter/pathology* ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Young Adult
Emotional abuse ; Emotional dysregulation ; Major depressive disorder ; Orbitofrontal cortex ; Physical abuse ; Voxel-based morphometry
BACKGROUND: Patients with major depressive disorder (MDD) present heterogeneous clinical symptoms, and childhood abuse is associated with deepening of psychopathology. The aim of this study was to identify structural brain abnormalities in MDD and to assess further differences in gray matter density (GMD) associated with childhood abuse in MDD. METHODS: Differences in regional GMD between 34 MDD patients and 26 healthy controls were assessed using magnetic resonance imaging and optimized voxel-based morphometry. Within the MDD group, further comparisons were performed focusing on the experience of maltreatment during childhood (23 MDD with child abuse vs 11 MDD without child abuse). RESULTS: Compared with healthy controls, the MDD patient group showed decreased GMD in the bilateral orbitofrontal cortices, right superior frontal gyrus, right posterior cingulate gyrus, bilateral middle occipital gyri, and left cuneus. In addition, the patient group showed increased GMD in bilateral postcentral gyri, parieto-occipital cortices, putamina, thalami, and hippocampi, and left cerebellar declive and tuber of vermis. Within the MDD patient group, the subgroup with abuse showed a tendency of decreased GMD in right orbitofrontal cortex, but showed increased GMD in the left postcentral gyrus compared to the subgroup without abuse. CONCLUSIONS: Our findings suggest a complicated dysfunction of networks between cortical-subcortical circuits in MDD. In addition, increased GMD in postcentral gyrus and a possible reduction of GMD in the orbitofrontal cortex of MDD patients with abuse subgroup may be associated with abnormalities of body perception and emotional dysregulation.
Files in This Item:
T201605236.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kyeong, Sung Hyon(경성현)
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Chung, Tae Sub(정태섭)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.