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Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients

Authors
 Chang-Yun Yoon  ;  Jimin Park  ;  Changhwan Seo  ;  Bo Young Nam  ;  Seonghun Kim  ;  Youn Kyung Kee  ;  Misol Lee  ;  Min-Uk Cha  ;  Hyoungnae Kim  ;  Seohyun Park  ;  Hae-Ryong Yun  ;  Su-Young Jung  ;  Jong Hyun Jhee  ;  Young Eun Kwon  ;  Meiyan Wu  ;  Jae Eun Um  ;  Hye-Young Kang  ;  Jung Tak Park  ;  Seung Hyeok Han  ;  Shin-Wook Kang  ;  Hyeon Chang Kim  ;  Sungha Park  ;  Sung-Kil Lim  ;  Tae-Hyun Yoo 
Citation
 JOURNAL OF BONE AND MINERAL RESEARCH, Vol.31(12) : 2149-2158, 2016 
Journal Title
JOURNAL OF BONE AND MINERAL RESEARCH
ISSN
 0884-0431 
Issue Date
2016
Abstract
Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1?±?11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32-2.81?ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio?=?0.719; 95% confidence interval [CI] 0.522-0.989; p?=?0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p?=?0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio?=?0.855; 95% CI 0.743-0.984; p?=?0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients. ? 2016 American Society for Bone and Mineral Research.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2907/abstract
DOI
10.1002/jbmr.2907
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kang, Hye Young(강혜영)
Kwon, Young Eun(권영은)
Kee, Youn Kyung(기연경)
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Kim, Hyoung Rae(김형래)
Nam, Bo Young(남보영)
Park, Seo Hyun(박서현)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Seo, Changhwan(서창환)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Yoon, Chang Yun(윤창연)
Yun, Hae Ryong(윤해룡) ORCID logo https://orcid.org/0000-0002-7038-0251
Lee, Mi Sol(이미솔)
Lim, Sung Kil(임승길)
Jung, Su Young(정수영)
Jhee, Jong Hyun(지종현)
Cha, Min Uk(차민욱)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152700
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