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Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author권영은-
dc.contributor.author기연경-
dc.contributor.author김현창-
dc.contributor.author남보영-
dc.contributor.author박서현-
dc.contributor.author김형래-
dc.contributor.author박정탁-
dc.contributor.author서창환-
dc.contributor.author유태현-
dc.contributor.author윤창연-
dc.contributor.author윤해룡-
dc.contributor.author박성하-
dc.contributor.author임승길-
dc.contributor.author정수영-
dc.contributor.author지종현-
dc.contributor.author차민욱-
dc.contributor.author한승혁-
dc.contributor.author이미솔-
dc.contributor.author강혜영-
dc.date.accessioned2017-10-26T07:55:37Z-
dc.date.available2017-10-26T07:55:37Z-
dc.date.issued2016-
dc.identifier.issn0884-0431-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152700-
dc.description.abstractRecent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1?±?11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32-2.81?ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio?=?0.719; 95% confidence interval [CI] 0.522-0.989; p?=?0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p?=?0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio?=?0.855; 95% CI 0.743-0.984; p?=?0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients. ? 2016 American Society for Bone and Mineral Research.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Society for Bone and Mineral Research-
dc.relation.isPartOfJOURNAL OF BONE AND MINERAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLow Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorChang-Yun Yoon-
dc.contributor.googleauthorJimin Park-
dc.contributor.googleauthorChanghwan Seo-
dc.contributor.googleauthorBo Young Nam-
dc.contributor.googleauthorSeonghun Kim-
dc.contributor.googleauthorYoun Kyung Kee-
dc.contributor.googleauthorMisol Lee-
dc.contributor.googleauthorMin-Uk Cha-
dc.contributor.googleauthorHyoungnae Kim-
dc.contributor.googleauthorSeohyun Park-
dc.contributor.googleauthorHae-Ryong Yun-
dc.contributor.googleauthorSu-Young Jung-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorYoung Eun Kwon-
dc.contributor.googleauthorMeiyan Wu-
dc.contributor.googleauthorJae Eun Um-
dc.contributor.googleauthorHye-Young Kang-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSung-Kil Lim-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1002/jbmr.2907-
dc.contributor.localIdA00232-
dc.contributor.localIdA00276-
dc.contributor.localIdA01142-
dc.contributor.localIdA01251-
dc.contributor.localIdA01495-
dc.contributor.localIdA01147-
dc.contributor.localIdA01654-
dc.contributor.localIdA04957-
dc.contributor.localIdA02526-
dc.contributor.localIdA02613-
dc.contributor.localIdA04617-
dc.contributor.localIdA01512-
dc.contributor.localIdA03375-
dc.contributor.localIdA04667-
dc.contributor.localIdA03970-
dc.contributor.localIdA05046-
dc.contributor.localIdA04304-
dc.contributor.localIdA02771-
dc.contributor.localIdA00096-
dc.contributor.localIdA00053-
dc.relation.journalcodeJ01278-
dc.identifier.eissn1523-4681-
dc.identifier.pmid27390906-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jbmr.2907/abstract-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKwon, Young Eun-
dc.contributor.alternativeNameKee, Youn Kyung-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameNam, Bo Young-
dc.contributor.alternativeNamePark, Seo Hyun-
dc.contributor.alternativeNameKim, Hyoung Rae-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameSeo, Changhwan-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameYoon, Chang Yun-
dc.contributor.alternativeNameYun, Hae Ryong-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameJung, Su Young-
dc.contributor.alternativeNameJhee, Jong Hyun-
dc.contributor.alternativeNameCha, Min Uk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameLee, Mi Sol-
dc.contributor.alternativeNameKang, Hye Young-
dc.contributor.affiliatedAuthorKwon, Young Eun-
dc.contributor.affiliatedAuthorKee, Youn Kyung-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorNam, Bo Young-
dc.contributor.affiliatedAuthorPark, Seo Hyun-
dc.contributor.affiliatedAuthorKim, Hyoung Rae-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorSeo, Changhwan-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorYoon, Chang Yun-
dc.contributor.affiliatedAuthorYun, Hae Ryong-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorJung, Su Young-
dc.contributor.affiliatedAuthorJhee, Jong Hyun-
dc.contributor.affiliatedAuthorCha, Min Uk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorLee, Mi Sol-
dc.contributor.affiliatedAuthorKang, Hye Young-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.citation.volume31-
dc.citation.number12-
dc.citation.startPage2149-
dc.citation.endPage2158-
dc.identifier.bibliographicCitationJOURNAL OF BONE AND MINERAL RESEARCH, Vol.31(12) : 2149-2158, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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