117 162

Cited 5 times in

Thyroid nodules with nondiagnostic results on repeat fine-needle aspiration biopsy: which nodules should be considered for repeat biopsy or surgery rather than follow-up?

Authors
 Na Lae Eun  ;  Mi Ri Yoo  ;  Hye Mi Gweon  ;  Ah Young Park  ;  Jeong-Ah Kim  ;  Ji Hyun Youk  ;  Hee Jung Moon  ;  Hang-Seok Chang  ;  Eun Ju Son 
Citation
 ULTRASONOGRAPHY, Vol.35(3) : 234-243, 2016 
Journal Title
 ULTRASONOGRAPHY 
ISSN
 2288-5919 
Issue Date
2016
Keywords
Biopsy, fine-needle ; Thyroid nodule ; Ultrasonography
Abstract
Purpose: The goal of this study was to assess the clinicopathologic and ultrasonographic features of thyroid nodules with nondiagnostic results on repeat ultrasonography (US)-guided fineneedle aspiration biopsy (FNAB) according to size and the number of suspicious findings and to determine the proper management of nodules with consecutive nondiagnostic results. Methods: This retrospective study included 297 nodules with nondiagnostic results on repeat FNAB that were evaluated by US over the course of at least 12 months of follow-up, a follow-up biopsy, or an operation. We compared clinical and US variables between benign and malignant nodules in thyroid nodules with repeat nondiagnostic results. Results: The comparison of benign and malignant nodules with repeat nondiagnostic results revealed that age, marked hypoechogenicity, irregular or microlobulated margins, microcalcifications, and nonparallel shape were significantly associated with malignancy. Multivariate logistic regression analysis in malignant nodules revealed that microcalcifications and irregular or microlobulated margins were independently associated with malignancy. Among them, only irregular or microlobulated margins were independently significant as a predictor of malignancy in repeatedly nondiagnostic nodules measuring >10 mm. Using receiver operating characteristic analysis, the best cutoff value for the “number of suspicious findings” between benign and malignant nodules was three in nodules of all sizes, three in nodules measuring ≤10 mm, and two in nodules measuring >10 mm. Conclusion: Irregular or microlobulated margins may be the most frequent US features in repeatedly nondiagnostic nodules >10 mm. The presence of “two or more suspicious findings” can be used as the cutoff for distinguishing benign and malignant nodules.
Files in This Item:
T201604211.pdf Download
DOI
10.14366/usg.15079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Gweon, Hye Mi(권혜미) ORCID logo https://orcid.org/0000-0002-3054-1532
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Ah Young(박아영)
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Yoo, Mi Ri(유미리)
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Eun, Na Lae(은나래) ORCID logo https://orcid.org/0000-0002-7299-3051
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152325
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse