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Optic nerve integrity as a visuospatial cognitive predictor in Parkinson's disease

Authors
 Jae Jung Lee  ;  Na-Young Shin  ;  Yoonju Lee  ;  Seung-Koo Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.31 : 41-45, 2016 
Journal Title
 PARKINSONISM & RELATED DISORDERS 
ISSN
 1353-8020 
Issue Date
2016
MeSH
Aged ; Anisotropy ; Cognition Disorders/etiology* ; Diffusion Tensor Imaging ; Female ; Follow-Up Studies ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Neuropsychological Tests ; Optic Nerve/diagnostic imaging ; Optic Nerve/pathology* ; Parkinson Disease/complications* ; Parkinson Disease/pathology* ; Positron-Emission Tomography ; Retrospective Studies ; Spatial Processing/physiology* ; Statistics as Topic ; Tropanes
Keywords
Cognition ; Diffusion tensor image ; Optic nerve ; Parkinson’s disease
Abstract
OBJECTIVE: To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS: We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), and 36 controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured on the mid-portion of the intraorbital optic nerve. Using a multivariate analysis of variance with repeated measures, longitudinal changes in cognitive subscores of a comprehensive neuropsychological test were evaluated in PD patients according to optic nerve integrity. RESULTS: The mean FA value in PD was significantly lower (0.552 ± 0.103, p < 0.001) than that in DIP (0.645 ± 0.099) or the controls (0.689 ± 0.089), whereas the mean ADC value was significantly higher in the PD group compared to the DIP or control group (p < 0.001). Optic nerve integrity was not associated with parkinsonian motor severity, striatal dopamine transporter activity, olfaction, or baseline cognitive performance in PD patents. In a longitudinal assessment of cognition in PD, the lower FA group showed significant decline in the performance of Clock Drawing Test (F = 3.39, p = 0.038), but no significant differences in the other cognitive subsets. CONCLUSION: This study demonstrated that microstructural integrity in the optic nerve was distorted in PD patients, and that this nerve integrity might act as a cognitive predictor of visuospatial dysfunction.
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802016302401?via%3Dihub
DOI
10.1016/j.parkreldis.2016.06.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Yoon Ju(이윤주)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152245
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