0 231

Cited 2 times in

Comparison of the oral microbiome of siblings using next-generation sequencing: a pilot study

DC FieldValueLanguage
dc.contributor.author김백일-
dc.contributor.author김성오-
dc.contributor.author송제선-
dc.contributor.author이제호-
dc.contributor.author이지현-
dc.date.accessioned2017-10-26T07:20:53Z-
dc.date.available2017-10-26T07:20:53Z-
dc.date.issued2016-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151909-
dc.description.abstractOBJECTIVE: The purpose of this study was to compare the oral microbiome of siblings with and without dental caries using next-generation sequencing. MATERIALS AND METHODS: To investigate the oral microbiome composition, 14 young siblings, seven with caries and seven without, were enrolled from seven sibling-pair families. Supragingival plaque samples were collected from the cervicobuccal area of posterior teeth. All samples were analyzed by pyrosequencing, based on the 16S rRNA gene hypervariable regions, V1-V4. RESULTS: The organisms identified belonged to 65 genera. Fifty-two genera were identified in the subjects with caries and 58 in those without; 45 genera were shared by both groups. In the Shannon index, the caries group showed lower bacterial diversity than the caries-free group and the difference was significant (Wilcoxon signed-rank test, P < 0.05). Additionally, similarities between siblings were evident in analyses based on weighted UniFrac distances (P < 0.05). CONCLUSIONS: In this study, the diversity of the microbiome was reduced in subjects with dental caries, while similarity between siblings seemed to be retained.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMunksgaard-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHDental Caries/microbiology-
dc.subject.MESHHumans-
dc.subject.MESHMouth/microbiology*-
dc.subject.MESHPilot Projects-
dc.subject.MESHSiblings-
dc.titleComparison of the oral microbiome of siblings using next-generation sequencing: a pilot study-
dc.typeArticle-
dc.publisher.locationDenmark-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Preventive Dentistry-
dc.contributor.googleauthorH-S Lee-
dc.contributor.googleauthorJH Lee-
dc.contributor.googleauthorS-O Kim-
dc.contributor.googleauthorJS Song-
dc.contributor.googleauthorBI Kim-
dc.contributor.googleauthorYJ Kim-
dc.contributor.googleauthorJ-H Lee-
dc.identifier.doi10.1111/odi.12491-
dc.contributor.localIdA00577-
dc.contributor.localIdA02058-
dc.contributor.localIdA03134-
dc.contributor.localIdA03214-
dc.contributor.localIdA00485-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid27087538-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/odi.12491/abstract-
dc.subject.keyworddental caries-
dc.subject.keywordnext-generation sequencing-
dc.subject.keywordoral microbiome-
dc.subject.keywordpyrosequencing-
dc.subject.keywordsibling-
dc.contributor.alternativeNameKim, Baek Il-
dc.contributor.alternativeNameKim, Seong Oh-
dc.contributor.alternativeNameSong, Je Seon-
dc.contributor.alternativeNameLee, Jae Ho-
dc.contributor.alternativeNameLee, Ji Hyun-
dc.contributor.affiliatedAuthorKim, Seong Oh-
dc.contributor.affiliatedAuthorSong, Je Seon-
dc.contributor.affiliatedAuthorLee, Jae Ho-
dc.contributor.affiliatedAuthorLee, Ji Hyun-
dc.contributor.affiliatedAuthorKim, Baek Il-
dc.citation.volume22-
dc.citation.number6-
dc.citation.startPage549-
dc.citation.endPage556-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.22(6) : 549-556, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.