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Cited 4 times in

Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

DC FieldValueLanguage
dc.contributor.author김철훈-
dc.contributor.author유제성-
dc.contributor.author이정호-
dc.contributor.author정성필-
dc.contributor.author정용은-
dc.contributor.author박인철-
dc.date.accessioned2017-10-26T07:17:43Z-
dc.date.available2017-10-26T07:17:43Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151848-
dc.description.abstractAcute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery occlusion model (4 h ischemia without reperfusion), hypothermia effectively reduces mean infarct volume. Hypothermia also prevents neurons in the infarct area from releasing high mobility group box 1 (HMGB1), the most well-studied damage-associated molecular pattern protein. By preventing its release, hypothermia also prevents the typical middle cerebral artery occlusion-induced increase in serum HMGB1. We also found that both glycyrrhizin-mediated inhibition of HMGB1 and intracerebroventricular neutralizing antibody treatments before middle cerebral artery occlusion onset diminish infarct volume. This suggests a clear neuroprotective effect of HMGB1 inhibition by hypothermia in the brain. We next used real-time polymerase chain reaction to measure the levels of pro-inflammatory cytokines in peri-infarct regions. Although middle cerebral artery occlusion increases the expression of interleukin-1β and tissue necrosis factor-α, this elevation is suppressed by both hypothermia and glycyrrhizin treatment. We show that hypothermia reduces the production of inflammatory cytokines and helps salvage peri-infarct regions from the propagation of ischemic injury via HMGB1 blockade. In addition to suggesting a potential mechanism for hypothermia's therapeutic effects, our results suggest HMGB1 modulation may lengthen the therapeutic window for stroke treatments.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfMOLECULAR BRAIN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Neutralizing/pharmacology-
dc.subject.MESHAntigens, Nuclear/metabolism-
dc.subject.MESHBrain Infarction/complications-
dc.subject.MESHBrain Infarction/pathology-
dc.subject.MESHBrain Ischemia/complications-
dc.subject.MESHBrain Ischemia/metabolism*-
dc.subject.MESHBrain Ischemia/pathology-
dc.subject.MESHBrain Ischemia/therapy*-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHGlycyrrhizic Acid/pharmacology-
dc.subject.MESHHMGB1 Protein/antagonists & inhibitors*-
dc.subject.MESHHMGB1 Protein/blood-
dc.subject.MESHHMGB1 Protein/metabolism-
dc.subject.MESHHypothermia, Induced*-
dc.subject.MESHInfarction, Middle Cerebral Artery/complications-
dc.subject.MESHInfarction, Middle Cerebral Artery/pathology-
dc.subject.MESHInflammation Mediators/metabolism-
dc.subject.MESHInjections, Intraventricular-
dc.subject.MESHMale-
dc.subject.MESHNerve Tissue Proteins/metabolism-
dc.subject.MESHRats, Wistar-
dc.titleHypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorJung Ho Lee-
dc.contributor.googleauthorEun Jang Yoon-
dc.contributor.googleauthorJeho Seo-
dc.contributor.googleauthorAdriana Kavoussi-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorSung Phil Chung-
dc.contributor.googleauthorIncheol Park-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorJe Sung You-
dc.identifier.doi10.1186/s13041-016-0260-0-
dc.contributor.localIdA02507-
dc.contributor.localIdA03130-
dc.contributor.localIdA03625-
dc.contributor.localIdA03662-
dc.contributor.localIdA01628-
dc.contributor.localIdA01057-
dc.relation.journalcodeJ02251-
dc.identifier.eissn1756-6606-
dc.identifier.pmid27544687-
dc.subject.keywordAcute ischemic stroke-
dc.subject.keywordGlycyrrhizin-
dc.subject.keywordHigh mobility group box 1 (HMGB1)-
dc.subject.keywordHypothermia-
dc.subject.keywordInflammatory cytokines-
dc.subject.keywordPenumbra-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.alternativeNameYou, Je Sung-
dc.contributor.alternativeNameLee, Jeong Ho-
dc.contributor.alternativeNameChung, Sung Pil-
dc.contributor.alternativeNameChung, Yong Eun-
dc.contributor.alternativeNamePark, In Cheol-
dc.contributor.affiliatedAuthorYou, Je Sung-
dc.contributor.affiliatedAuthorLee, Jeong Ho-
dc.contributor.affiliatedAuthorChung, Sung Pil-
dc.contributor.affiliatedAuthorChung, Yong Eun-
dc.contributor.affiliatedAuthorPark, In Cheol-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.citation.volume9-
dc.citation.startPage81-
dc.identifier.bibliographicCitationMOLECULAR BRAIN, Vol.9 : 81, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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