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In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

Authors
 Hanna Cho  ;  Jae Yong Choi  ;  Mi Song Hwang  ;  You Jin Kim  ;  Hye Mi Lee  ;  Hye Sun Lee  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
Citation
 Annals of Neurology, Vol.80(2) : 247-258, 2016 
Journal Title
 Annals of Neurology 
ISSN
 0364-5134 
Issue Date
2016
MeSH
Aged ; Alzheimer Disease/metabolism* ; Alzheimer Disease/pathology ; Amnesia/complications ; Amnesia/metabolism ; Amnesia/pathology ; Amyloid/metabolism* ; Atrophy/pathology ; Cerebral Cortex/metabolism* ; Cerebral Cortex/pathology ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/metabolism* ; Cognitive Dysfunction/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuroimaging ; Neuropsychological Tests ; Positron-Emission Tomography ; tau Proteins/metabolism*
Abstract
OBJECTIVE: To determine the in vivo cortical spreading pattern of tau and amyloid and to establish positron emission tomography (PET) image-based tau staging in the Alzheimer disease (AD) spectrum. METHODS: We included 195 participants (53 AD, 52 amnestic mild cognitive impairment [MCI], 23 nonamnestic MCI, and 67 healthy controls) who underwent 2 PET scans ((18) F-florbetaben for amyloid-β and (18) F-AV-1451 for tau). We assumed that regions with earlier appearances of pathology may show increased binding in a greater number of participants and acquired spreading order of tau accumulation by sorting the regional frequencies of involvement. We classified each participant into image-based tau stage based on the Z score of the composite region for each stage. RESULTS: Tau accumulation was most frequently observed in the medial temporal regions and spread stepwise to the basal and lateral temporal, inferior parietal, posterior cingulate, and other association cortices, and then ultimately to the primary cortical regions. In contrast, amyloid accumulation was found with similar frequency in the diffuse neocortical areas and then finally spread to the medial temporal regions. The image-based tau stage correlated with the general cognitive status, whereas cortical thinning was found only in the advanced tau stages: medial temporal region in stage V and widespread cortex in stage VI. INTERPRETATION: Our PET study replicated postmortem spreading patterns of tau and amyloid-β pathologies. Unlike the diffuse accumulation of amyloid throughout the neocortex, tau spreading occurred in a stepwise fashion through the networks. Image-based tau staging may be useful for the objective assessment of AD progression
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ana.24711/abstract
DOI
10.1002/ana.24711
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Mi(이혜미)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151818
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