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Retinal Artery Occlusion and the Risk of Stroke Development: Twelve-Year Nationwide Cohort Study

 Tyler Hyungtaek Rim  ;  Jinu Han  ;  Yoon Seong Choi  ;  Seung-sik Hwang  ;  Christopher Seungkyu Lee  ;  Sung Chul Lee  ;  Sung Soo Kim 
 Stroke, Vol.47(2) : 376-382, 2016 
Journal Title
Issue Date
Age Factors ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Registries* ; Republic of Korea/epidemiology ; Retinal Artery Occlusion/epidemiology* ; Retrospective Studies ; Risk Factors ; Stroke/epidemiology*
atrial fibrillation ; retinal artery occlusion ; stroke
BACKGROUND AND PURPOSE: Our aim was to evaluate the risk of subsequent stroke development after retinal artery occlusion (RAO). METHODS: National registry data were collected from the Korean National Health Insurance Service, comprised 1 025 340 random subjects. Patients diagnosed with RAO in 2002 and 2003 were excluded. The RAO group was composed of patients with an initial diagnosis of either central or other RAO between January 2004 and December 2013 (n=401). The comparison group was composed of randomly selected patients (5 per RAO patient; n=2003) who were matched to the RAO group according to sociodemographic factors and year of RAO diagnosis. Each sampled patient was tracked until 2013. Cox proportional hazard regression was used. RESULTS: Stroke occurred in 15.0% of the RAO group and in 8.0% of the comparison group (P < 0.001). RAO was associated with an increased risk of stroke occurrence (hazard ratio, 1.78; 95% confidence interval, 1.32-2.41). The magnitude of the RAO effect for stroke was larger among younger adults aged <65 years (hazard ratio, 3.11) than older adults aged ≥65 years (hazard ratio, 1.26). However, the risk of subsequent stroke was significantly increased in older adults aged ≥65 years at the 4-year follow-up (hazard ratio, 1.58; 95% confidence interval, 1.01-2.48). CONCLUSIONS: RAO was significantly associated with subsequent stroke after adjusting for comorbidities and sociodemographic factors. These findings are limited by uncontrolled confounding factors and need to be replicated by other observational studies.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김성수(Kim, Sung Soo) ORCID logo https://orcid.org/0000-0002-0574-7993
이성철(Lee, Sung Chul) ORCID logo https://orcid.org/0000-0001-9438-2385
이승규(Lee, Christopher Seungkyu) ORCID logo https://orcid.org/0000-0001-5054-9470
임형택(Rim, Tyler Hyungtaek)
최윤성(Choi, Yoon Seong)
한진우(Han, Jinu) ORCID logo https://orcid.org/0000-0002-8607-6625
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