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The feasibility of CT lung volume as a surrogate marker of donor-recipient size matching in lung transplantation

 Woo Sang Jung  ;  Seokjin Haam  ;  Jae Min Shin  ;  Kyunghwa Han  ;  Chul Hwan Park  ;  Min Kwang Byun  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Tae Hoon Kim 
 Medicine, Vol.95(27) : 3957-3957, 2016 
Journal Title
Issue Date
Aged ; Feasibility Studies ; Female ; Humans ; Lung/anatomy & histology* ; Lung/diagnostic imaging* ; Lung/physiology ; Lung Transplantation* ; Male ; Middle Aged ; Organ Size ; Respiratory Function Tests ; Retrospective Studies ; Tissue Donors ; Tomography, X-Ray Computed* ; Total Lung Capacity
CT lung volume ; lung transplantation ; predicted total lung capacity ; size matching ; total lung capacity
Donor-recipient size matching in lung transplantation (LTx) by computed tomography lung volume (CTvol) may be a reasonable approach because size matching is an anatomical issue. The purpose of this study is to evaluate the feasibility of CTvol as a surrogate marker of size matching in LTx by comparing CTvol and predicted total lung capacity (pTLC) to reference total lung capacity (TLC) values.From January to December 2014, data from 400 patients who underwent plethysmography, pulmonary function testing (PFT), and chest computed tomography scans were reviewed retrospectively. Enrolled 264 patients were divided into 3 groups according to PFT results: Group I, obstructive pattern; Group II, restrictive pattern; Group III, normal range. The correlations between pTLC and TLC and between CTvol and TLC were analyzed, and the linear correlation coefficients were compared. The percentage error rates of pTLC and CTvol were calculated and absolute error rates were compared.The correlation coefficient between CTvol and TLC in Group I was larger than that of pTLC and TLC (0.701 vs 0.432, P = 0.002). The absolute percentage error rate between CTvol and pTLC was lower than that of pTLC in Group II (15.3%?±?11.9% vs 42.2%?±?28.1%, P?<?0.001).CTvol showed similar or better correlation with TLC compared to the pTLC in normal participants and patients with obstructive or restrictive pulmonary diseases. CTvol showed a smaller error rate in patients with restrictive disease. The results suggest that CTvol may be a feasible method for size matching in LTx.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
신재민(Shin, Jae Min)
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
정우상(Jung, Woo Sang)
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